Table 4 Univariable and multivariable models of breast cancer-specific mortality in central breast cancer patients
From: Breast conserving therapy for central breast cancer in the United States
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |
Surgery type | < 0.001 | < 0.001 | ||
Non-BCT | Reference | Reference | ||
BCT | 0.266 (0.206–0.342) | < 0.001 | 0.570 (0.435–0.746) | < 0.001 |
Age | < 0.001 | 0.894 | ||
< 45 | Reference | Reference | ||
45–59 | 1.131 (0.843–1.518) | 0.411 | 1.075 (0.79–1.463) | 0.645 |
60–79 | 1.904 (1.437–2.524) | < 0.001 | 1.069 (0.785–1.455) | 0.672 |
Race | < 0.001 | < 0.001 | ||
White | Reference | Reference | ||
Black | 1.505 (1.218–1.859) | < 0.001 | 1.473 (1.137–1.91) | 0.003 |
Others | 0.581 (0.429–0.787) | < 0.001 | 0.549 (0.374–0.806) | 0.002 |
Marital | < 0.001 | 0.007 | ||
Married | Reference | Reference | ||
Single | 1.355 (1.097–1.672) | 0.005 | 1.244 (0.957–1.618) | 0.103 |
Divorced | 1.478 (1.243–1.758) | < 0.001 | 1.43 (1.141–1.792) | 0.002 |
Year of diagnosis | 0.935 (0.882–0.99) | 0.022 | 0.949 (0.881–1.022) | 0.167 |
Grade | < 0.001 | < 0.001 | ||
Grade I | Reference | Reference | ||
Grade II | 1.04 (0.804–1.346) | 0.763 | 1.763 (1.109–2.803) | 0.017 |
Grade III | 1.612 (1.233–2.106) | 0 | 3.159 (1.984–5.029) | < 0.001 |
Grade IV | 2.439 (0.977–6.091) | 0.056 | 4.019 (1.179–13.706) | 0.026 |
T stage | < 0.001 | < 0.001 | ||
T1 | Reference | Reference | ||
T2 | 1.616 (1.329–1.966) | < 0.001 | 1.913 (1.441–2.54) | < 0.001 |
T3 | 2.241 (1.733–2.897) | < 0.001 | 2.798 (1.998–3.919) | < 0.001 |
T4 | 3.251 (2.487–4.25) | < 0.001 | 4.072 (2.868–5.782) | < 0.001 |
N stage | < 0.001 | < 0.001 | ||
N0 | Reference | Reference | ||
N1 | 1.532 (1.264–1.857) | < 0.001 | 1.907 (1.465–2.483) | < 0.001 |
N2 | 2.725 (2.151–3.452) | < 0.001 | 3.525 (2.599–4.781) | < 0.001 |
N3 | 3.518 (2.706–4.573) | < 0.001 | 4.546 (3.282–6.297) | < 0.001 |
ER status | 0.003 | 0.005 | ||
Negative | Reference | |||
Positive | 0.695 (0.546–0.885) | 0.003 | Reference | 0.005 |
PR status | < 0.001 | < 0.001 | ||
Negative | Reference | Reference | ||
Positive | 0.664 (0.534–0.825) | < 0.001 | 0.519 (0.395–0.681) | < 0.001 |
HER-2 status | 0.045 | 0.008 | ||
Negative | Reference | Reference | ||
Positive | 0.818 (0.672–0.995) | 0.045 | 0.723 (0.569–0.918) | 0.008 |