From: Breast conserving therapy for central breast cancer in the United States
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |
Surgery type | < 0.001 | < 0.001 | ||
Non-BCT | Reference | |||
BCT | 0.396 (0.332–0.473) | < 0.001 | 0.633 (0.522–0.766) | < 0.001 |
Age | < 0.001 | < 0.001 | ||
< 45 | Reference | Reference | ||
45–59 | 1.029 (0.769–1.378) | 0.846 | 1.188 (0.885–1.595) | 0.252 |
60–79 | 1.581 (1.201–2.080) | 0.001 | 2.012 (1.518–2.668) | < 0.001 |
Race | < 0.001 | < 0.001 | ||
White | Reference | Reference | ||
Black | 1.922 (1.568–2.356) | < 0.001 | 1.509 (1.222–1.864) | < 0.001 |
Others | 0.630 (0.466–0.851) | 0.003 | 0.566 (0.418–0.767) | < 0.001 |
Marital | < 0.001 | < 0.001 | ||
Married | Reference | Reference | ||
Single | 1.596 (1.301–1.959) | < 0.001 | 1.366 (1.106–1.686) | 0.004 |
Divorced | 1.829 (1.544–2.166) | < 0.001 | 1.465 (1.231–1.742) | < 0.001 |
Year of diagnosis | 0.929 (0.877–0.984) | 0.012 | 0.941 (0.888–0.997) | 0.038 |
Grade | < 0.001 | < 0.001 | ||
Grade I | Reference | Reference | ||
Grade II | 1.392 (1.081–1.793) | 0.01 | 1.025 (0.792–1.326) | 0.85 |
Grade III | 3.189 (2.497–4.071) | < 0.001 | 1.581 (1.211–2.065) | 0.001 |
Grade IV | 4.950 (2.004–12.224) | 0.001 | 2.438 (0.977–6.08) | 0.056 |
T stage | < 0.001 | < 0.001 | ||
T1 | Reference | Reference | ||
T2 | 2.288 (1.906–2.747) | < 0.001 | 1.48 (1.214–1.805) | < 0.001 |
T3 | 4.055 (3.208–5.126) | < 0.001 | 1.947 (1.498–2.529) | < 0.001 |
T4 | 6.933 (5.452–8.817) | < 0.001 | 2.845 (2.169–3.731) | < 0.001 |
N stage | < 0.001 | < 0.001 | ||
N0 | Reference | Reference | ||
N1 | 1.83 (1.525–2.195) | < 0.001 | 1.461 (1.205–1.772) | < 0.001 |
N2 | 3.999 (3.214–4.976) | < 0.001 | 2.482 (1.956–3.149) | < 0.001 |
N3 | 6.087 (4.802–7.716) | < 0.001 | 3.180 (2.443–4.140) | < 0.001 |
ER status | < 0.001 | 0.003 | ||
Negative | Reference | Reference | ||
Positive | 0.362 (0.307–0.427) | < 0.001 | 0.692 (0.544–0.880) | 0.003 |
PR status | < 0.001 | < 0.001 | ||
Negative | Reference | Reference | ||
Positive | 0.407 (0.350–0.475) | < 0.001 | 0.666 (0.536–0.828) | < 0.001 |
HER-2 status | 0.004 | 0.039 | ||
Negative | Reference | Reference | ||
Positive | 1.318 (1.094–1.588) | 0.004 | 0.813 (0.668–0.989) | 0.039 |