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Table 1 Baseline characteristics and univariate analysis

From: Duration of postoperative hyperlactatemia has predictive value in recurrent fistula after major definitive surgery for intestinal fistula

 

RF group A (n = 7)

Non-RF group A (n = 46)

p

RF group B (n = 53)

Non-RF group B (n = 126)

p

RF group B (n = 37)

Non-RF group B (n = 46)

p

Female, No. (%)

3 (42.86)

25 (54.35)

0.570

26 (49.06)

67 (53.17)

0.615

15 (40.54)

21 (45.65)

0.640

Age, year (median, IQR)

56 (44–60)

54 (37–58)

0.107

52 (39–60)

53 (36–63)

0.751

56 (37–67.5)

54 (39–65)

0.620

BMI, kg/m2 (mean ± SD)

20 (19–20.5)

19.5 (19–20.5)

0.847

20 (19–21)

20 (19–21)

0.576

20 (19–20)

19.5 (19–21)

0.328

Etiology, No. (%)

  

0.431

  

0.489

  

0.766

 Trauma

4 (57.14)

14 (30.43)

 

15 (28.30)

32 (25.39)

 

18 (48.64)

19 (41.30)

 

 Obstruction due to previous surgerya

0

9 (19.56)

 

5 (9.43)

20 (15.87)

 

2 (5.41)

2 (4.35)

 

 Mesenteric thrombosis

0

2 (4.35)

 

2 (3.77)

4 (3.17)

 

2 (5.41)

1 (2.17)

 

 Tumour

3 (42.86)

16 (34.78)

 

11 (20.75)

45 (35.71)

 

6 (16.21)

12 (26.08)

 

 Appendicitis

0

5 (10.87)

 

0

0

 

0

0

 

 Pancreatitis

0

0

 

12 (22.64)

25 (19.84)

 

9 (24.32)

12 (26.09)

 

Location of the fistula, No. (%)

  

0.412

  

0.113

  

0.102

Duodenum

3 (42.86)

14 (30.43)

 

22 (41.51)

40 (31.75)

 

18 (48.64)

17 (36.96)

 

Stomach

1 (14.29)

4 (8.69)

 

0

4 (3.17)

 

1 (2.7)

0

 

Gastrojejunal anastomotic

1 (14.29)

0

 

7 (13.20)

9 (7.14)

 

7 (18.92)

4 (8.69)

 

Jejunum/ileum

0

12 (26.08)

 

9 (16.98)

40 (31.75)

 

4 (10.81)

16 (34.78)

 

Ileocolonic anastomosis or appendiceal stumpb

0

11 (23.91)

 

1 (1.89)

7 (5.55)

 

1 (2.7)

3 (6.52)

 

 Colon

2 (28.57)

5 (10.87)

 

14 (26.41)

26 (20.63)

 

6 (16.21)

6 (13.04)

 

Interval from fistula occurred to admission, days, (median, IQR)

21 (14–30)

23 (14–29)

0.182

23 (20–32)

23 (20–30)

0.575

24 (20–34)

24 (22–34)

0.771

Interval from fistula occurred to definitive surgery, days, (median, IQR)

125 (105–141)

120 (102–129)

0.198

121 (109–140)

120 (105–138)

0.509

126 (114–144)

122 (110–135)

0.176

Enteroatmospheric fistula, No. (%)

2 (28.57)

3 (6.52)

0.124

22 (41.51)

43 (34.12)

0.384

22 (59.46)

19 (41.30)

0.100

Preoperative albumin, g/L, (median, IQR)

37 (35–40)

38 (36–39)

0.690

38 (36–39)

37 (36–39)

0.695

37 (36–38)

38 (36–39)

0.107

Preoperative hemoglobin, g/L, (median, IQR)

112 (110–125)

119 (111–125)

0.867

117 (110–124)

121 (115–126)

0.035

118 (114–126)

121 (114–124)

0.656

Grade of abdominal adhesions, No. (%)

  

0.031

  

0.037

  

0.576

 III

3 (42.86)

37 (80.43)

 

7 (13.21)

14 (11.11)

 

N/A

N/A

 

 IV

4 (57.14)

9 (19.56)

 

26 (49.06)

86 (68.25)

 

10 (27.02)

10 (21.74)

 

 V

N/A

N/A

 

20 (37.74)

26 (23.02)

 

27 (72.98)

36 (78.26)

 

Blood loss during definitive surgery, mL (median, IQR)

800 (700–1100)

600 (500–700)

 < 0.001

1500 (1250–1600)

1250 (1000–1537)

0.002

2250 (1650–2850)

2041 (1265–2633)

 < 0.001

Duration of definitive surgery, min (median, IQR)

163 (141–170)

138 (131–150)

0.003

228 (211–246)

230 (206–253)

0.534

278 (227–315)

268 (234–305)

0.985

Intraoperative red blood cell transfusion, Unit (median, IQR)

2 (2–3)

2 (2–2)

0.671

4 (4–4)

4 (4–4)

0.359

5 (4–6)

5 (4–6)

0.599

Postoperative red blood cell transfusion within 48 h after definitive surgeryb, Unit (median, IQR)

3 (3–4)

2 (0–3)

0.001

6 (6–7)

4 (4–6)

 < 0.001

10 (6–11)

9 (5–11)

 < 0.001

Postoperative Albumin transfusion within 48 h after definitive surgeryc, g (median, IQR)

60 (40–80)

40 (20–50)

0.003

100 (85–160)

120 (120–180)

0.008

200 (100–210)

180 (170–190)

 < 0.001

Postoperative positive fluid balance 48 h after surgery, No. (%)

3 (42.86)

8 (17.39)

0.122

24 (19.04)

30 (23.81)

0.004

28 (75.68)

26 (56.52)

0.069

Time for lactate recovery to < 2 mmol/L after definitive surgery, hours (median, IQR)

24 (12–24)

12 (12–24)

0.387

48 (IQR 48–72)

24 (IQR: 24–48)

p < 0.001

72 (IQR 48–72)

48 (IQR:24–48)

p < 0.001

Comorbidity, No. (%)

         

 Hypertension

0

2 (4.35)

1.000

5 (9.43)

10 (7.93)

0.302

4 (10.81)

5 (10.87)

1.000

 Diabetes mellitus

1 (14.28)

0

0.132

6 (11.32)

7 (5.56)

0.175

6 (16.22)

4 (8.69)

0.295

 Chronic hepatitis

1 (14.29)

1 (2.17)

0.249

2 (3.77)

4 (3.17)

1.000

2 (5.41)

1 (2.17)

0.583

  1. aBefore admission, the patient received surgical treatment of intestinal obstruction following a previous abdominal surgery
  2. bIn order to maintain the Hemoglobin > 100 g/L within 48 h after definitive surgery
  3. cIn order to maintain the Albumin > 30 g/L within 48 h after definitive surgery