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Table 1 Comparison of clinicopathological features between GADVR tumor thrombus and non-GADVR tumor thrombus

From: Renal cell carcinoma with tumor thrombus growing against the direction of venous return: an indicator of complicated surgery and poor prognosis

 

non-GADVR (n = 192)

GADVR (n = 21)

P

Gender, n (%)

0.988

 Male

146 (76.0%)

16 (76.2%)

 

 Female

46 (24.0%)

5 (23.8%)

 

Age, y, median (IQR)

60.00 (14.00)

59.00 (10.00)

0.550

Clinical symptoms, n (%)

0.068

 No

50 (26.0%)

1 (4.8%)

 

 Local symptoms

94 (49.0%)

16 (76.2%)

 

 Systemic symptoms

12 (6.2%)

1 (4.8%)

 

 Both

36 (18.8%)

3 (14.2%)

 

BMI, kg/m2, mean ± SD

23.87 ± 3.91

24.95 ± 2.66

0.220

Surgical approach, n (%)

0.035*

 Laparoscope

92 (47.9%)

5 (23.8%)

 

 Open

100 (52.1%)

16 (76.2%)

 

Mayo classification, n (%)

0.093

 0

54 (28.1%)

2 (9.5%)

 

 1

34 (17.7%)

3 (14.3%)

 

 2

70 (36.5%)

12 (57.2%)

 

 3

19 (9.9%)

4 (19.0%)

 

 4

15 (7.8%)

0 (0%)

 

IVC segmental resection, n (%)

< 0.001*

 No

162 (84.4%)

8 (38.1%)

 

 Yes

30 (15.6%)

13 (61.9%)

 

Preoperative serum creatinine, µmol/L, median (IQR)

91.00 (27.00)

110.00 (34.00)

0.015*

Serum creatinine 1 week after operation, µmol/L, median (IQR)

97.00 (33.00)

96.00 (47.00)

0.739

Side, n (%)

0.392

 Left

73 (38.0%)

10 (47.6%)

 

 Right

119 (62.0%)

11 (52.4%)

Tumor diameter, cm, mean ± SD

8.94 ± 3.15

8.42 ± 2.52

0.472

Clinical N stage, n (%)

0.123

 cN0

79 (41.1%)

5 (23.8%)

 

 cN1

113 (58.9%)

16 (76.2%)

 

Adrenal metastasis, n (%)

0.613

 No

176 (91.7%)

18 (85.7%)

 

 Yes

16 (8.3%)

3 (14.3%)

 

Distant metastasis, n (%)

0.328

 No

136 (70.8%)

17 (81.0%)

 

 Yes

56 (29.2%)

4 (19.0%)

 

Bland thrombus, n (%)

< 0.001*

 No

154 (80.2%)

9 (42.9%)

 

 Yes

38 (19.8%)

12 (57.1%)

 

Sarcomatoid feature, n (%)

1.000

 No

167 (87.0%)

18 (85.7%)

 

 Yes

25 (13.0%)

3 (14.3%)

 

Perirenal fat infiltration, n (%)

  

0.728

 No

130 (67.7%)

15 (71.4%)

 

 Yes

62 (32.3%)

6 (28.6%)

 

Pathology type, n (%)

1.000

 Clear cell RCC

160 (83.3%)

17 (81.0%)

 

 Non‐clear cell RCC

32 (16.7%)

4 (19.0%)

 

Nuclear grade, n (%)

0.528

 1

3 (1.6%)

0 (0%)

 

 2

70 (36.4%)

8 (38.1%)

 

 3

76 (39.6%)

11 (52.4%)

 

 4

43 (22.4%)

2 (9.5%)

 

Lymph node dissection, n (%)

0.830

 No

105 (54.7%)

12 (57.1%)

 

 Yes

87 (45.3%)

9 (42.9%)

 

ASA grade, n (%)

0.816

 1

13 (6.8%)

2 (9.5%)

 

 2

156 (81.2%)

17 (81.0%)

 

 3

23 (12.0%)

2 (9.5%)

 

Operative time, min, median (IQR)

308.00 (158.00)

379.00 (138.00)

0.038*

Surgical blood loss, mL, median (IQR)

600.00 (1550.00)

1400.00 (850.00)

0.018*

Postoperative complication, n (%)

0.045*

 No

133 (69.3%)

10 (47.6%)

 

 Yes

59 (30.7%)

11 (52.4%)

 

Severe postoperative complication, n (%)

0.912

 No

180 (93.8%)

19 (90.5%)

 

 Yes

12 (6.2%)

2 (9.5%)

 

Thrombus adhering to the IVC, n (%)

0.002*

 No

104 (54.2%)

4 (19.0%)

 

 Yes

88 (45.8%)

17 (81.0%)

 
  1. GADVR growing against the direction of venous return, IQR interquartile range, BMI body mass index, SD standard deviation, RCC renal cell carcinoma, ASA American Society of Anesthesiologists, IVC inferior vena cava 
  2. *p<0.05