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Table 2 In hospital outcome of patients treated with DAPT or aspirin alone

From: Dual antiplatelet therapy before coronary artery bypass grafting in patients with myocardial infarction: a prospective cohort study

Parameter

Univariate

Multipled

Aspirin alone

DAPT

p

OR/Coef.

95% CI

p

CABG in first day

2 (1.6)

8 (6.7)

0.057b

–

–

–

CABG after 24 h

122 (98.4)

112 (93.3)

0.057b

–

–

–

Cardio-bypass time (min)

108.7 ± 30.4

112.4 ± 56.3

0.552

–

–

–

Cross-clamp time (min)

66.7 ± 18.6

66.6 ± 29.3

0.979

–

–

–

Need to blood transfusion

110 (88.7)

101 (84.2)

0.300

–

–

–

Number of pack cell transfusion

2.4 ± 1.5

2.6 ± 1.8

0.560

–

–

–

Blood transfusion during surgery

      

 1 unit

88 (71.0)

88 (73.3)

0.026a

1.2

0.5, 3.0

0.681

 2 units

12 (9.7)

3 (2.5)

    

 3 units

2 (1.6)

0 (0.0)

    

Haemoglobin 1 day(mg/dL)

9.4 ± 1.8

9.5 ± 1.9

0.502

–

–

–

Haemoglobin 2 day(mg/dL)

10.3 ± 1.4

10.2 ± 1.3

0.930

–

–

–

Cr 1 day (mg/dL)

1.4 ± 1.1

1.4 ± 0.8

0.817

–

–

–

Cr 2 day (mg/dL)

1.3 ± 1.0

1.2 ± 0.9

0.889

–

–

–

Duration of IABP

   

–

–

–

 No

124 (100.0)

116 (97.5)

0.117b

–

–

–

 Yes

0 (0.0)

3 (2.5)

    

Minor bleeding

0 (0.0)

0 (0.0)

–

–

–

–

Major bleeding

0 (0.0)

0 (0.0)

–

–

–

–

Retroperitoneal bleeding

0 (0.0)

0 (0.0)

–

–

–

–

Hematoma

0 (0.0)

0 (0.0)

–

–

–

–

GI bleeding

0 (0.0)

0 (0.0)

–

–

–

–

Repeated sternotomy

4 (3.2)

0 (0.0)

0.122b

–

–

–

Recurrent ischemia

0 (0.0)

0 (0.0)

–

–

–

–

Recurrent MI

0 (0.0)

1 (0.8)

0.496b

–

–

–

Stent thrombosis

0 (0.0)

1 (0.8)

0.492

–

–

–

CVA

2 (1.6)

7 (5.8)

0.098

–

–

–

Death

2 (1.6)

7 (5.8)

0.098

–

–

–

Death in cat-Lab

0 (0.0)

0 (0.0)

–

–

–

–

Later in-hospital death

2 (1.6)

9 (7.5)

0.028

4.2

0.9, 20.5

0.071

Hospital stay (day)

13.6 ± 5.4

15.6 ± 12.0

0.113

–

–

–

ICU stay (day)

5.0 ± 1.9

5.8 ± 3.4

0.045

0.7

− 0.2, 1.6

0.109

EF (%) after surgery

46.4 ± 8.9

44.4 ± 9.5

0.693c

–

–

–

 ≥ 55%

27 (23.9)

23 (21.1)

0.267b

–

–

–

 40–54%

70 (62.0)

63 (57.8)

    

 35–40%

5 (4.4)

8 (7.3)

    

 < 35%

11 (9.7)

15 (13.8)

    

EF change (%)

− 0.22 ± 4.3

0.4 ± 5.6

0.336

–

–

–

Diastolic dysfunction grade

      

 0

4 (3.7)

6 (5.7)

0.651b

–

–

–

 1

101 (94.4)

98 (92.4)

    

 2

1 (0.9)

2 (1.9)

    

 3

1 (0.9)

0 (0.0)

    

PAP

26.0 ± 6.9

25.1 ± 7.0

0.364

–

–

–

Total cost

237.8 ± 57.5

289.2 ± 88.3

 < 0.001

22.7

− 0.2, 45.6

0.052

Insurance cost

191.5 ± 59.6

236.0 ± 71.1

 < 0.001

18.8

− 1.8, 39.3

0.074

Patient cost

34.7 ± 33.8

35.3 ± 20.4

0.878

–

–

–

  1. Bold values are significant
  2. Data are presented as n (%) or mean ± standard deviation
  3. Coef. linear regression coefficient; CVA cerebrovascular accident; EF ejection fraction; GI glycemic index; IABP intra-aortic balloon pump; ICU intensive care unit; LOS length of stay; MI myocadial infarction; OR odds ratio; PAP pulmonary artery pressure; PCI percutaneous coronary intervention
  4. aBased on Kruskal–Wallis test
  5. bBased of Fisher’s exact test
  6. cAdjusted for ejection fraction values at before surgery using ANCOVA test
  7. dAdjusted for body mass index, ejection fraction at before surgery, history of dyslipidemia, history of COPD, history of PCI, history of aspirin and statin consumption, presence of mitral regurgitation and application of primary PCI before surgery using multiple logistic or multiple linear regression tests