Table 3 Comparison of inclusion criteria for IORT between our study and the ELIOT and TARGIT-A studies

Age—yrs

≥ 45

48 ≤ age < 75

≥ 45

Histology sub-type

Invasive ductal carcinoma

Invasive carcinoma (unifocal)

Invasive carcinoma

Lobular carcinoma (with MRI and radio-concologist confirmation)

Lobular carcinoma (with MRI confirmation)

No lobular

DCIS (low and intermiediat grade, tumor size ≤ 2.5 sm and margin of 2–3 mm)

–

–

Tumor size

45–50 years old then 0–2 cm

≤ 2.5 cm

< 2 cm or < 3.5 (with N0-1 and M0 with cytology or histology confirmation)

50–55 years old then < 2.5 cm

–

–

> 55 years old then < 3 cm

–

–

Marginal status

Invasive tumor = negative margin

–

–

DCIS ≥ 3 mm

–

–

Nodal status

Negative

–

–

Or micro-metastasis

–

–

Hormone receptor status

ER + 

–

–

Others

–

–

Previously diagnosed and treated contralateral breast cancer