Lipid changes during the perioperative period in patients with early breast cancer: a real-world retrospective analysis

Table 4 Factors identified to be associated with the increase in lipid profiles based on multivariate analysis, by stepwise logistic regression

	Univariate analysis			Multivariate analysis
	OR	95% CI for OR	p	OR	95% CI for OR	p
TG: increase (n = 1151) vs not increase (n = 783)
Age
≤ 40	1
40–50	1.067	0.825–1.381	0.622
> 50	0.712	0.548–0.926	0.011
Premenopause
Pre-	1
Post-	0.671	0.557–0.808	< 0.001
ER
ER−	1
ER+	1.570	1.293–1.905	< 0.001
PR
PR−	1			1
PR+	1.656	1.371–2.000	< 0.001	1.411	1.046–1.904	0.024
Preoperative hyperlipidemia	2.212	1.838–2.663	< 0.001	2.121	1.745–2.578	< 0.001
TC: increase (n = 785) vs no increase (n = 1149)
Premenopause
Pre-	1
Post-	0.801	0.664–0.966	0.02
ER
ER−	1
ER+	1.253	1.029–1.526	0.025
PR
PR−	1			1
PR+	1.409	1.163–1.707	< 0.001	1.479	1.093–2.003	0.011
Preoperative hyperlipidemia	1.710	1.419–2.061	< 0.001	1.672	1.376–2.030	< 0.001
LDL: increase (n = 1009) vs not increase (n = 925)
Premenopause
Pre-	1
Post-	0.813	0.676–0.976	0.027
ER
ER−	1
ER+	1.349	1.112–1.635	0.002
PR
PR−	1			1
PR+	1.443	1.196–1.740	< 0.001	1.407	1.164–1.701	< 0.001
Preoperative hyperlipidemia	1.863	1.552–2.237	< 0.001	1.838	1.530–2.209	< 0.001

TG triglycerides, TC total cholesterols, LDL low-density lipoprotein, ER estrogen receptor, PR progesterone receptor

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