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Table 3 Multivariate analysis of clinical pathology and prognosis of 2917 BC patients with bone metastasis

From: Impact of surgery on survival in breast cancer with bone metastases only: a SEER database retrospective analysis

Variables

Regression coefficient

Standard error

P-value

HR

95%CI

Marital

     

Married

Reference

    

Unmarried

0.193

0.056

0.001

1.213

1.087–1.354

Age

     

 ≤ 35

Reference

    

35 < age < 60

− 0.07

0.147

0.635

0.933

0.700–1.243

 ≥ 60

0.258

0.147

0.08

1.294

0.970–1.727

Race

     

White

Reference

    

Black

0.267

0.071

 < 0.001

1.306

1.135–1.502

Other

0.001

0.113

0.995

1.001

0.802–1.248

Histology

     

IDC

Reference

    

Non-IDC

0.331

0.065

 < 0.001

1.392

1.225–1.583

Primary surgery

     

Non-operation

Reference

    

Operation

− 0.644

0.059

 < 0.001

0.525

0.467–0.590

Chemotherapy

     

Yes

Reference

    

No

0.383

0.061

 < 0.001

1.467

1.302–1.653

T stage

     

T1

Reference

    

T2

0.116

0.091

0.2

1.123

0.940–1.341

T3

0.247

0.099

0.013

1.28

1.054–1.555

T4

0.321

0.093

0.001

1.379

1.149–1.654

Radiation

     

Yes

Reference

    

No

− 0.011

0.055

0.849

0.99

0.888–1.103

Grade

     

1

Reference

    

2

0.234

0.1

0.02

1.263

1.038–1.538

3–4

0.583

0.105

 < 0.001

1.791

1.459–2.199

HER2

     

Positive

Reference

    

Negative

0.571

0.082

 < 0.001

1.771

1.508–2.079

ER

     

Positive

Reference

    

Negative

0.589

0.095

 < 0.001

1.802

1.496–2.170

PR

     

Positive

reference

    

Negative

0.442

0.073

 < 0.001

1.556

1.348–1.797

Subtype

     

ER + /HER2−

Reference

    

ER + /HER2 + 

− 0.243

0.091

0.007

0.785

0.657–0.937

HER2 + 

− 2.024

0.353

 < 0.001

0.132

0.066–0.264

TNBC

− 0.547

0.322

0.089

0.579

0.308–1.088

Surgical mode

     

Non-operation

Reference

    

BCS

− 0.93

0.099

 < 0.001

0.394

0.325–0.478

Mastectomy

− 0.702

0.108

 < 0.001

0.496

0.401–0.613

Radical mastectomy

− 0.488

0.071

 < 0.001

0.614

0.534–0.706

  1. ER estrogen receptor, PR progesterone receptor, Her-2 human epidermal growth factor receptor 2, IDC infiltrating ductal carcinoma, BCS breast conserving surgery, TNBC triple-negative breast cancer