Impact of surgery on survival in breast cancer with bone metastases only: a SEER database retrospective analysis

BMC Surgery

Table 3 Multivariate analysis of clinical pathology and prognosis of 2917 BC patients with bone metastasis

Variables	Regression coefficient	Standard error	P-value	HR	95%CI
Marital
Married	Reference
Unmarried	0.193	0.056	0.001	1.213	1.087–1.354
Age
≤ 35	Reference
35 < age < 60	− 0.07	0.147	0.635	0.933	0.700–1.243
≥ 60	0.258	0.147	0.08	1.294	0.970–1.727
Race
White	Reference
Black	0.267	0.071	< 0.001	1.306	1.135–1.502
Other	0.001	0.113	0.995	1.001	0.802–1.248
Histology
IDC	Reference
Non-IDC	0.331	0.065	< 0.001	1.392	1.225–1.583
Primary surgery
Non-operation	Reference
Operation	− 0.644	0.059	< 0.001	0.525	0.467–0.590
Chemotherapy
Yes	Reference
No	0.383	0.061	< 0.001	1.467	1.302–1.653
T stage
T1	Reference
T2	0.116	0.091	0.2	1.123	0.940–1.341
T3	0.247	0.099	0.013	1.28	1.054–1.555
T4	0.321	0.093	0.001	1.379	1.149–1.654
Radiation
Yes	Reference
No	− 0.011	0.055	0.849	0.99	0.888–1.103
Grade
1	Reference
2	0.234	0.1	0.02	1.263	1.038–1.538
3–4	0.583	0.105	< 0.001	1.791	1.459–2.199
HER2
Positive	Reference
Negative	0.571	0.082	< 0.001	1.771	1.508–2.079
ER
Positive	Reference
Negative	0.589	0.095	< 0.001	1.802	1.496–2.170
PR
Positive	reference
Negative	0.442	0.073	< 0.001	1.556	1.348–1.797
Subtype
ER + /HER2−	Reference
ER + /HER2 +	− 0.243	0.091	0.007	0.785	0.657–0.937
HER2 +	− 2.024	0.353	< 0.001	0.132	0.066–0.264
TNBC	− 0.547	0.322	0.089	0.579	0.308–1.088
Surgical mode
Non-operation	Reference
BCS	− 0.93	0.099	< 0.001	0.394	0.325–0.478
Mastectomy	− 0.702	0.108	< 0.001	0.496	0.401–0.613
Radical mastectomy	− 0.488	0.071	< 0.001	0.614	0.534–0.706

ER estrogen receptor, PR progesterone receptor, Her-2 human epidermal growth factor receptor 2, IDC infiltrating ductal carcinoma, BCS breast conserving surgery, TNBC triple-negative breast cancer

ISSN: 1471-2482