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Table 1 Characteristics of patients with intrahepatic cholangiocarcinoma which underwent surgery (N = 251)

From: The role of lymph node dissection in intrahepatic cholangiocarcinoma: a multicenter retrospective study

 

LND (N = 177,76.3%)

nLND (N = 55,23.7%)

P value

Sex

   

Female

86 (48.6)

19 (34.5)

0.68

Male

91 (51.4)

36 (65.5)

 

Age (year)

   

 ≤ 60

103 (58.2)

32 (58.2)

0.99

 > 60

74 (41.8)

23 (41.8)

 

BMI (kg/m2)

   

 < 25

105 (59.3)

26 (47.3)

0.12

 ≥ 25

72 (40.7)

29 (52.7)

 

LNM positive

   

Yes

71 (40.1)

NA

 

No

106 (59.9)

  

LND number

   

 < 6

111 (62.7)

NA

 

 ≥ 6

66 (37.3)

  

LNM number

   

0

106 (60.6)

NA

 

1 to 3

50 (28.6)

  

 > 3

19 (10.9)

  

POD time (day)

   

 ≤ 9

76 (43.2)

35 (63.6)

 < 0.01

 > 9

100 (56.8)

20 (36.4)

 

HbsAg + 

   

Yes

32 (18.7)

9 (18.0)

0.90

No

139 (81.3)

41 (82.0)

 

CEA (ng/mL)

   

 ≤ 7

135 (80.4)

46 (86.8)

0.29

 > 7

33 (19.6)

7 (13.2)

 

CA19-9 (U/mL)

   

 ≤ 75

75 (44.6)

36 (75.0)

 < 0.01

 > 75

93 (55.4)

12 (25.0)

 

ALT (U/L)

   

 ≤ 50

137 (77.4)

52 (94.5)

 < 0.01

 > 50

40 (22.6)

3 (5.5)

 

TBIL (μmol/L)

   

 ≤ 21

145 (81.9)

48 (87.3)

0.35

 > 21

32 (18.1)

7 (12.7)

 

ALB (g/L)

   

 < 35

18 (10.2)

2 (3.6)

0.13

 ≥ 35

159 (89.8)

53 (96.4)

 

ASA Score

   

 ≤ 2

159 (89.8)

53 (96.4)

0.13

 > 2

18 (10.2)

2 (3.6)

 

Cirrhosis

   

No

28 (15.8)

16 (29.1)

0.03

Yes

149 (84.2)

39 (70.9)

 

Comorbidity

   

No

99 (55.9)

32 (58.2)

0.77

Yes

78 (44.1)

23 (41.8)

 

Operation time (min)

 ≤ 235

81 (45.8)

42 (76.4)

 < 0.01

 > 235

96 (54.2)

13 (23.6)

 

Blood loss (mL)

   

 ≤ 300

85 (48.0)

38 (69.1)

 < 0.01

 > 300

92 (52.0)

17 (30.9)

 

Intraoperative blood transfusion

No

106 (59.9)

42 (76.4)

0.03

Yes

71 (40.1)

13 (23.6)

 

Tumor size (cm)

   

 ≤ 6

99 (55.9)

36 (65.5)

0.21

 > 6

78 (44.1)

19 (34.5)

 

Multi-disease

   

Yes

33 (18.6)

7 (12.7)

0.31

No

144 (81.4)

48 (87.3)

 

Margin + 

   

Yes

22 (12.4)

2 (3.6)

0.06

No

155 (87.6)

53 (96.4)

 

Differentiation

   

Poorly

70 (39.5)

22 (40.0)

0.95

Moderately + well

107 (60.5)

33 (60)

 

Vascular invasion

   

Yes

87 (49.2)

15 (27.3)

 < 0.01

No

90 (50.8)

40 (72.7)

 

Nerve invasion

   

Yes

60 (33.9)

7 (12.7)

 < 0.01

No

117 (66.1)

48 (87.3)

 

T stage

   

T1

101 (57.1)

47 (85.5)

 < 0.01

 > T1

76 (42.9)

8 (14.5)

 

Adjuvant chemotherapy

Yes

66 (37.3)

21 (38.2)

0.90

No

111 (62.7)

34 (61.8)