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Table 1 The characteristics of included studies

From: The comparison of albumin and 6% hydroxyethyl starches (130/0.4) in cardiac surgery: a meta-analysis of randomized controlled clinical trials

Trials Centers Number of patients Area Gender M/Fa Age (years old)a Type of surgery Purpose
Niemi et al. (2008) Single 30 Finland 9/6 vs. 11/4 61 (31–78) vs. 59 (34–73)b On-pump cardiac surgery Infusion fluid
Schramko et al. (2009) Single 30 Finland 11/4 vs. 9/6 61 (48) vs. 59 (39) c Elective primary cardiac surgery Infusion fluid
Choi et al. (2010) Single 36 South Korea 6/12 vs. 5/13 55 ± 14 vs. 54 ± 12 Elective mitral valvular heart surgery with CPB Priming solution
Cho et al. (2014) Single 54 Korea 7/11 vs. 7/11 57 ± 17 vs. 64 ± 13 Complex cardiac surgery Priming solution
Skhirtladze et al. (2014) Single 240 Austria 53/23 vs. 52/29 66 (23–85) vs. 67 (28–87)b Elective cardiovascular surgery with CPB Infusion fluid
Maleki et al. (2016) Single 60 Iran 21/9 vs. 17/13 66.07 ± 8.82 vs. 61.85 ± 9.10 Elective coronary artery bypass grafting surgery Priming solutions
Duncan et al. (2020) Single 141 America 47/22 vs. 44/28 71 (10)vs. 69 (9)c Elective aortic valve replacement Volume replacement
Hanart et al. (2009) Single 119 Italy 38/21 vs. 32/28 0.91 (0.42–3.5) vs. 1.67 (0.67–3.83)b Congenital heart disease necessitating CPB Intraoperative fluid volume replacement
Van der Linden et al. (2013) Two-center 61 Belgium and Austria 17/13 vs. 15/16 4.0 (2–9) vs. 5.2 (2–12)b Elective cardiac surgery for congenital heart disease requiring the extracorporeal circulation device Volume replacement
Patel et al. (2016) Single 70 India 21/14 vs. 24/11 15.80 ± 13.11 vs. 16.20 ± 14.24 Cardiac surgery with CPB Priming solution
  1. M/F male/female, CPB cardiopulmonary bypass, of 1567 patients [1221]
  2. aHA vs. 6%HES 130/0.4; bInterquartile range; cRange