Table 1 The characteristics of included studies
Trials | Centers | Number of patients | Area | Gender M/Fa | Age (years old)a | Type of surgery | Purpose |
|---|---|---|---|---|---|---|---|
Niemi et al. (2008) | Single | 30 | Finland | 9/6 vs. 11/4 | 61 (31–78) vs. 59 (34–73)b | On-pump cardiac surgery | Infusion fluid |
Schramko et al. (2009) | Single | 30 | Finland | 11/4 vs. 9/6 | 61 (48) vs. 59 (39) c | Elective primary cardiac surgery | Infusion fluid |
Choi et al. (2010) | Single | 36 | South Korea | 6/12 vs. 5/13 | 55 ± 14 vs. 54 ± 12 | Elective mitral valvular heart surgery with CPB | Priming solution |
Cho et al. (2014) | Single | 54 | Korea | 7/11 vs. 7/11 | 57 ± 17 vs. 64 ± 13 | Complex cardiac surgery | Priming solution |
Skhirtladze et al. (2014) | Single | 240 | Austria | 53/23 vs. 52/29 | 66 (23–85) vs. 67 (28–87)b | Elective cardiovascular surgery with CPB | Infusion fluid |
Maleki et al. (2016) | Single | 60 | Iran | 21/9 vs. 17/13 | 66.07 ± 8.82 vs. 61.85 ± 9.10 | Elective coronary artery bypass grafting surgery | Priming solutions |
Duncan et al. (2020) | Single | 141 | America | 47/22 vs. 44/28 | 71 (10)vs. 69 (9)c | Elective aortic valve replacement | Volume replacement |
Hanart et al. (2009) | Single | 119 | Italy | 38/21 vs. 32/28 | 0.91 (0.42–3.5) vs. 1.67 (0.67–3.83)b | Congenital heart disease necessitating CPB | Intraoperative fluid volume replacement |
Van der Linden et al. (2013) | Two-center | 61 | Belgium and Austria | 17/13 vs. 15/16 | 4.0 (2–9) vs. 5.2 (2–12)b | Elective cardiac surgery for congenital heart disease requiring the extracorporeal circulation device | Volume replacement |
Patel et al. (2016) | Single | 70 | India | 21/14 vs. 24/11 | 15.80 ± 13.11 vs. 16.20 ± 14.24 | Cardiac surgery with CPB | Priming solution |