Skip to main content

Table 3 Differentiating neuroendocrine tumors with immunohistochemical markers

From: Pitfalls in the management of subglottic paragangliomas at unusual location: a case report and literature review

Immunohistochemical
markers
Paraganglioma Typical carcinoid Atypical carcinoid Small cell neuroendocrine tumor MTC FTC
1.Neuro-specific enolase (+) (+) (+) (+) (+) (−)
2.Chromogranin A (+) (+) (+) (+) (+) (+)
3.Synaptophysin (+) (+) (+) (+) (+) (−)
4.Glial fibrillary acidic protein* (+) (−) (−) (−) (+) (−)
5.S-100 protein* (+) (−) (−) (−) (−) (−)
6.Cytokeratin (−) (+) (+) (+) (+) (+)
7.Calcitonin (−) (+) (+) (+)/(−) (+) (+)
8.CEA (−) (+) (+) (+) (+) (+)
9.EMA (−) (+) (+) (+) (+) (+)
10. TTF1 (−) (−) (−) (+)/(−) (+) (+)
11. MIB-1 (−) (−) (−) (−) (−) (+)
  1. MTC medullary thyroid carcinoma; FTC follicular thyroid carcinoma; CEA carcinoembryonic antigen; EMA epithelial membrane antigen; TTF-1 thyroid transcription factor 1; MIB-1 molecular immunology Borstel number 1
  2. *Positivity only in the sustentacular cells