Table 3 Differentiating neuroendocrine tumors with immunohistochemical markers
Immunohistochemical markers | Paraganglioma | Typical carcinoid | Atypical carcinoid | Small cell neuroendocrine tumor | MTC | FTC |
|---|---|---|---|---|---|---|
1.Neuro-specific enolase | (+) | (+) | (+) | (+) | (+) | (−) |
2.Chromogranin A | (+) | (+) | (+) | (+) | (+) | (+) |
3.Synaptophysin | (+) | (+) | (+) | (+) | (+) | (−) |
4.Glial fibrillary acidic protein* | (+) | (−) | (−) | (−) | (+) | (−) |
5.S-100 protein* | (+) | (−) | (−) | (−) | (−) | (−) |
6.Cytokeratin | (−) | (+) | (+) | (+) | (+) | (+) |
7.Calcitonin | (−) | (+) | (+) | (+)/(−) | (+) | (+) |
8.CEA | (−) | (+) | (+) | (+) | (+) | (+) |
9.EMA | (−) | (+) | (+) | (+) | (+) | (+) |
10. TTF1 | (−) | (−) | (−) | (+)/(−) | (+) | (+) |
11. MIB-1 | (−) | (−) | (−) | (−) | (−) | (+) |