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Table 5 Sexually-related outcomes

From: A systematic review and meta-analysis of risks and benefits with breast reduction in the public healthcare system: priorities for further research

Author
Year
Country
Study design Number of patients Withdrawals—dropouts Intervention
Breast reduction
Mean (SD)
Control
No surgery
Mean (SD)
P values of intergroup difference if not state otherwise
Comments Directness* Study limitations* Precision*
Beraldo
2016
Brazil [41]
RCT I: 30
C: 30
I: 1
C: 3
Sexual function
Baseline: 24.7 (8.8)
6 months: 27.5 (6.9)
Sexual function
Baseline: 23.9 (9.6)
p = 0.96
6 months: 22.5 (9.3)
p < 0.001
MD 5.0
Female Sexual Function Index (FSFI). The questionnaire includes 19 questions on sexual activity during the last 4 weeks. It has 6 domains: desire, arousal, lubrication, orgasm, satisfaction, and discomfort/pain. A higher score means a better function. A total score of 26.55 or less indicates sexual dysfunction
A MID of 4.2 has been suggested for FSFI [65]
? ? ?
Andrade
2018
Brazil [42]
Non-randomized controlled study I: 50
C: 50
NR Sexual well-being
6 months-1 year:
88 (21–100) median (range)
Sexual well-being
29 (0–78) median (range)
p = 0.001
MD 66
Sexual well-being domain of BREAST-Q (reduction/ mastopexy module)
Score 0–100, a higher score means better outcome
Baseline values are not given
 +  - ?/ + 
Janik
2019
Poland [62]
Non-randomized controlled study I: 75
C: 27
NR Sexual quality of life
12–36 months: 76.7 (11.6)
(mean follow-up 23.6 months)
Sexual quality of life
64.4 (13.7)
p < 0.01
MD 12
Sexual Quality of Life-Female (SQoL-F): 18 items, each scored from 1–6, total score 18–108
Higher score better
 +  - -
     Sexual function
12–36 months:
27.4 (9.1)
Sexual function
Pre-operative:
21 (11.4)
p = 0.03
Female Sexual Function Index (FSFI). Higher score better    
     Sexual well-being
12–36 months:
72 (14)
Sexual well-being
Pre-operative:
39.3 (14.5)
p < 0.01
Sexual well-being domain of BREAST-Q (reduction/ mastopexy module). Baseline values not reported    
  1. * + No or minor problems; ? Some problems; - Major problems