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Table 1 PICO

From: A systematic review and meta-analysis of risks and benefits with breast reduction in the public healthcare system: priorities for further research

PICO
P Women who seek health care for symptomatic breast hypertrophy and with a BMI ≤ 35
Excluded: Women operated for breast cancer or who have had a breast augmentation
I Breast reduction
C C1: no treatment
C2: non-surgical treatment
O Critical for decision-making
  Mortality
  Complications
  Health related Quality of Life (HRQoL)
  Important for decision-making
  Depressive symptoms
  Anxiety symptoms
  Sexuality-related outcomes
  Work ability
  Sick leave
Physical function
  Pain
  Experiences of having a breast reduction
  Patient-reported outcomes had to be measured with validated scales