Table 1 PICO

P

Women who seek health care for symptomatic breast hypertrophy and with a BMI ≤ 35

Excluded: Women operated for breast cancer or who have had a breast augmentation

I

Breast reduction

C

C1: no treatment

C2: non-surgical treatment

O

Critical for decision-making

Mortality

Complications

Health related Quality of Life (HRQoL)

Important for decision-making

Depressive symptoms

Anxiety symptoms

Sexuality-related outcomes

Work ability

Sick leave

Physical function

Pain

Experiences of having a breast reduction

Patient-reported outcomes had to be measured with validated scales