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Table 2 Univariable and multivariable analysis of factors associated with OS of CRLM after first recurrence

From: Recurrent colorectal liver metastasis patients could benefit from repeat hepatic resection

  Univariable analysis Multivariable analysis
HR 95% P value HR 95% P value
Age
 > 70 Ref 0.869–2.461 0.153 Ref 0.777–2.366 0.284
 ≤ 70 1.462 1.356
Sex
 Male Ref 0.670–1.322 0.726 Ref 0.586–1.201 0.336
 Female 0.941 0.838
Primary T stage
 1–2 Ref 0.515–1.355 0.465 Ref 0.502–1.424 0.529
 3–4 0.835 0.846
Primary N stage
 N0 Ref 1.265–2.734 0.002 Ref 1.227–2.809 0.003
 N1-2 1.860 1.857
Location tumor
 Colon Ref 0.600–1.159 0.279 Ref 0.517–1.187 0.249
 Rectum 0.834 0.783
Primary tumor location
 Left Ref 0.834–1.734 0.322 Ref 0.770–1.973 0.383
 Right 1.203 1.233
Timing of liver metastasis
 > 12 month Ref 0.588–1.435 0.708 Ref 0.613–1.644 0.970
 ≤ 12 month 0.981 1.010
CEA
 > 50 Ref 0.451–1.443 0.455 Ref 0.408–1.515 0.472
 ≤ 50 0.798 0.786
CA199
 > 100 Ref 0.675–1.974 0.600 Ref 0.690–2.333 0.444
 ≤ 100 1.154 1.269
Tumor size
 ≤ 3 cm Ref 1.074–2.222 0.035 Ref 1.037–2.810 0.036
 > 3 cm 1.441 1.707
Tumor no
 ≤ 1 Ref 1.006–1.942 0.046 Ref 0.424–1.268 0.733
 > 1 1.398 0.733
RAS status
 Wild Ref 1.183–2.281 0.003 Ref 1.080–2.234 0.017
 Mutation 1.634 1.553
Distribution
 Unilobar Ref 1.094–2.205 0.014 Ref 0.806–2.380 0.238
 Bilobar 1.553 1.385
Early recurrence
 No Ref 1.387–2.725 0.000 Ref 1.148–2.523 0.008
 Yes 1.944 1.702
Local treatment
 No Ref 0.222–0.443 0.000 Ref 0.218–0.467 0.000
 Yes 0.313 0.322