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Fig. 5 | BMC Surgery

Fig. 5

From: Identification of potential hub genes associated with skin wound healing based on time course bioinformatic analyses

Fig. 5

Hub cluster of DEGs in the inflammatory phase analyzed by protein–protein interaction (PPI) and hub genes related to KEGG pathway enrichment. A PPI interaction network. Green nodes represent downregulated genes; red nodes represent upregulated genes. PPI molecular complex detection method (MCODE) component. Two highest-scoring modules identified in the PPI network using the MCODE algorithm with scores of 34.176 (cluster 1) and 18.6 (cluster 2). B In cluster 1, 35 key genes were involved, and D 21 key genes in cluster 2 were involved. Key genes in cluster 1 (C) and cluster 2 (E) were annotated in the context of the KEGG database. The relationships between these annotated terms were calculated and grouped by ClueGO to create an annotation module network. Genes with connections having more than two terms were defined as key functional genes. F The top 10 hub genes in the PPI were screened by Cytoscape plugin cytoHubba based on their connectivity degree

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