Fig. 4

Differentially expressed genes (DEGs) in the inflammatory phase, and Gene Ontology (GO) and KEGG pathway analysis of DEGs. A Volcano plot representing DEGs on the third-postoperative-day (3rd POD) compared with intact skin (control). B Volcano plot representing DEGs on the seventh-postoperative-day (7th POD) compared with control. C Venn diagram displaying overlapping genes that were significantly differentially expressed on the 3rd and 7th POD, compared with the control. D Ten most significantly enriched KEGG pathways and numbers of genes involved; E Ten most significantly enriched GO terms for biological processes and numbers of genes involved; F Ten most significantly enriched GO terms for cellular components and numbers of genes involved gene numbers; G Ten most significantly enriched GO terms for molecular function of DEGs and numbers of genes involved, in the significantly differentially expressed overlapping genes on the 3rd and 7th POD compared with the control. P < 0.05 defined as significantly enriched