Fig. 3From: Identification of potential hub genes associated with skin wound healing based on time course bioinformatic analysesHub clusters of DEGs in the acute wound phase analyzed by protein–protein interaction (PPI) analysis and hub genes related to KEGG pathway enrichment. A PPI interaction network. Green nodes represent downregulated genes; red nodes represent upregulated genes. B PPI molecular complex detection method (MCODE) component. The highest scoring module identified from the PPI network using the MCODE algorithm with a score of 5.00, with five key genes involved. C Key genes in cluster 1 were annotated in the context of the KEGG database by ClueGO, of which 3 (TYR, TYRP1, and DCT) were enriched in the tyrosine metabolism pathway, and defined as key functional genes. D The top 10 hub genes in the PPI were screened by Cytoscape plugin cytoHubba based on their connectivity degreeBack to article page