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Table 5 Univariate and multivariate analysis of recurrence-free survival

From: Inflammatory indexes in preoperative blood routine to predict early recurrence of hepatocellular carcinoma after curative hepatectomy

Factors Univariate analysis Multivariate analysis
HR 95% CI P value HR 95% CI P value
Sex (male/female) 1.436 0.722–2.855 0.302
Age (≤ 55/> 55 years) 0.882 0.591–1.317 0.540
AST (≤ 40/> 40 U/L) 1.316 0.854–2.027 0.213
ALT (≤ 40/> 40 U/L) 1.018 0.674–1.538 0.933
Total bilirubin (< 17.1/≥ 17.1 umol/L) 1.032 0.649–1.642 0.893
Albumin (> 35/≥ 35 g/L) 0.678 0.393–1.167 0.160
Tumour size (≤ 5/> 5 cm) 2.283 1.523–3.422 < 0.001 1.768 1.144–2.732 0.010
Tumour number (solitary/multiple) 2.421 1.495–3.919 < 0.001 2.289 1.295–4.047 0.004
HBV infection (no/yes) 0.904 0.438–1.865 0.785
Liver cirrhosis (no/yes) 1.095 0.694–1.728 0.696
Vascular invasion (no/yes) 2.924 1.845–4.635 < 0.001 1.908 1.162–3.132 0.011
Differentiation (moderate and well/poor) 2.490 1.662–3.732 < 0.001 2.411 1.521–3.824 < 0.001
Blood transfusion (no/yes) 1.184 0.790–1.773 0.413
Hepatic hilar occlusion (no/yes) 1.130 0.757–1.687 0.551
SII (≤ 330/ > 330) 1.382 0.911–2.098 0.129
MLR (≤ 0.25/> 0.25) 3.801 2.341–6.171 < 0.001 2.037 1.154–3.597 0.014
NLR (≤ 2.74/> 2.74) 2.513 1.599–3.950 < 0.001 2.070 1.212–3.537 0.008
PLR (≤ 88/> 88) 1.404 0.938–2.100 0.099
SIRI (≤ 1.03/> 1.03) 2.248 1.496–3.378 < 0.001 1.320 0.773–2.255 0.309
AFP (< 400/≥ 400 ng/mL) 1.587 1.034–2.437 0.035 0.914 0.557–1.499 0.721
ALBI grade (1/2) 1.180 0.787–1.768 0.423
BCLC stage (0–A/B–C) 2.467 1.628–3.740 < 0.001 1.969 1.216–3.187 0.006
  1. HR hazard ratio
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