Table 5 Univariate and multivariate analysis of recurrence-free survival
Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Sex (male/female) | 1.436 | 0.722–2.855 | 0.302 | – | – | – |
Age (≤ 55/> 55 years) | 0.882 | 0.591–1.317 | 0.540 | – | – | – |
AST (≤ 40/> 40 U/L) | 1.316 | 0.854–2.027 | 0.213 | – | – | – |
ALT (≤ 40/> 40 U/L) | 1.018 | 0.674–1.538 | 0.933 | – | – | – |
Total bilirubin (< 17.1/≥ 17.1 umol/L) | 1.032 | 0.649–1.642 | 0.893 | – | – | – |
Albumin (> 35/≥ 35 g/L) | 0.678 | 0.393–1.167 | 0.160 | – | – | – |
Tumour size (≤ 5/> 5 cm) | 2.283 | 1.523–3.422 | < 0.001 | 1.768 | 1.144–2.732 | 0.010 |
Tumour number (solitary/multiple) | 2.421 | 1.495–3.919 | < 0.001 | 2.289 | 1.295–4.047 | 0.004 |
HBV infection (no/yes) | 0.904 | 0.438–1.865 | 0.785 | – | – | – |
Liver cirrhosis (no/yes) | 1.095 | 0.694–1.728 | 0.696 | – | – | – |
Vascular invasion (no/yes) | 2.924 | 1.845–4.635 | < 0.001 | 1.908 | 1.162–3.132 | 0.011 |
Differentiation (moderate and well/poor) | 2.490 | 1.662–3.732 | < 0.001 | 2.411 | 1.521–3.824 | < 0.001 |
Blood transfusion (no/yes) | 1.184 | 0.790–1.773 | 0.413 | – | – | – |
Hepatic hilar occlusion (no/yes) | 1.130 | 0.757–1.687 | 0.551 | – | – | – |
SII (≤ 330/ > 330) | 1.382 | 0.911–2.098 | 0.129 | – | – | – |
MLR (≤ 0.25/> 0.25) | 3.801 | 2.341–6.171 | < 0.001 | 2.037 | 1.154–3.597 | 0.014 |
NLR (≤ 2.74/> 2.74) | 2.513 | 1.599–3.950 | < 0.001 | 2.070 | 1.212–3.537 | 0.008 |
PLR (≤ 88/> 88) | 1.404 | 0.938–2.100 | 0.099 | – | – | – |
SIRI (≤ 1.03/> 1.03) | 2.248 | 1.496–3.378 | < 0.001 | 1.320 | 0.773–2.255 | 0.309 |
AFP (< 400/≥ 400 ng/mL) | 1.587 | 1.034–2.437 | 0.035 | 0.914 | 0.557–1.499 | 0.721 |
ALBI grade (1/2) | 1.180 | 0.787–1.768 | 0.423 | – | – | – |
BCLC stage (0–A/B–C) | 2.467 | 1.628–3.740 | < 0.001 | 1.969 | 1.216–3.187 | 0.006 |