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Table 3 Prognostic factors for recurrence-free-survival in 120 patients with well-differentiated PanNEN

From: Increased neutrophil–lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification

Independent factor

Univariate analysis

Multivariate analysis

Hazard ratio

95% CI

P‒value

Hazard ratio

95% CI

P‒value

Age (years)

  

0.101

   

 < 60

Reference

     

 ≥ 60

0.36

0.08‒1.21

    

Sex

  

0.09

   

 Female

Reference

     

 Male

2.66

0.84‒9.05

    

NLR

  

0.004

  

0.042

 < 2.62

Reference

  

Reference

  

 ≥ 2.62

5.78

1.81‒18.5

 

3.49

1.05‒11.7

 

Albumin (g/L)

  

0.829

   

 < 35

Reference

     

 ≥ 35

0.79

0.15‒14.5

    

Tumor size (mm)

  

 < 0.001

  

0.052

 < 25

Reference

  

Reference

  

 ≥ 25

10.2

3.05‒46.2

 

5.30

0.98‒81.5

 

Surgical margin status

  

0.337

   

 R0

Reference

     

 R1

2.74

0.35–21.5

    

Tumor location

  

0.619

   

 Head

Reference

     

 Body/tail

0.95

0.28‒2.99

    

 Multiple

NA

NA

    

Clinical stage

  

0.001

  

0.736

 I

Reference

  

Reference

  

 II/III

8.12

2.13‒52.9

 

1.19

0.06‒13.6

 

2017 WHO classification

  

 < 0.001

  

0.015

 G1

Reference

  

Reference

  

 G2/G3

15.6

3.02‒285.6

 

8.81

1.46‒168.2

 

Hormonal function

  

0.151

   

 No

Reference

     

 Yes

2.46

0.73‒11.1

    

Lymph node metastasis

  

0.063

   

 No

Reference

     

 Yes

3.49

0.93‒11.1

    

Lymphatic invasion

  

0.150

   

 No

Reference

     

 Yes

2.89

0.64‒9.77

    

Venous invasion

  

0.022

  

0.356

 No

Reference

  

Reference

  

 Yes

3.96

1.23‒12.7

 

1.17

0.29‒4.49

 
  1. Variables associated with RFS according to the Cox proportional hazards regression model
  2. RFS Recurrence-free-survival, NLR neutrophil–lymphocyte ratio, NA not available
  3. P-value < 0.05 marked in bold font shows statistical significance
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BMC Surgery

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