Table 3 Prognostic factors for OS for ICC patients in multivariate analysis

Age ≥ 60 years

–

–

–

–

RDW-SD > 40.2 fl

0.446 (0.262–0.760)

0.003

–

–

Male

–

–

–

RDW-CV > 12.6%

–

–

0.425 (0.230–0.783)

0.006

BMI ≥ 24 kg/m²

–

–

–

–

ALB ≥ 40 g/L

0.472 (0.257–0.866)

0.015

0.511 (0.269–0.974)

0.041

ASA score 3–4

–

–

–

–

TBIL > 21 umol/L

–

–

–

–

Cirrhosis

–

–

–

–

AST > 40 U/L

–

–

–

–

HBsAg ( +)

–

–

–

–

ALT > 50U/L

–

–

2.332 (0.984–5.528)

0.055

T3–T4 stage

–

–

–

–

Operation time ≥ 230 min^b

1.894 (1.097–3.270)

0.019

1.804 (1.030–3.161)

0.039

Lymphnode metastasis

–

 < 0.001

–

 < 0.001

Blood loss ≥ 300 ml^b

–

–

–

–

Undissected lymph node

Reference

Reference

Major liver resection

–

–

–

–

Negative lymph node

1.160 (0.581–2.318)

0.674

1.226 (0.595–2.526)

0.580

Post-operative Complications

–

–

–

–

Positive lymph node

3.715 (1.721–8.019)

0.001

4.394 (1.950–9.900)

 < 0.001

Preoperative therapy

–

–

–

–

Tumor size ≥ 5 cm

–

–

2.041 (1.134–3.673)

0.017

Adjuvant therapy

0.423 (0.232–0.774)

0.005

0.481 (0.264–0.876)

0.017

Multiple tumors

–

–

–

–

Multivariate analysis^c (Model 3)

Tumor location (central tumor)

0.367 (0.210–0.641)

 < 0.001

0.307 (0.171–0.552)

 < 0.001

HR (95%CI)

Value p

Tumor location (right lobe)

–

–

–

–

The prognostic value on SCC score^c

 < 0.001

Poor differentiation

–

–

–

–

SCC = 0

Reference

Preoperative CA19-9 > 27 U/mL

–

–

–

–

SCC = 1

0.296 (0.153–0.571)

 < 0.001

Preoperative CEA > 5 ng/mL

2.486 (1.305–4.734)

0.006

2.234 (1.164–4.287)

0.016

SCC = 2

0.270 (0.133–0.549)

 < 0.001