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Table 1 Characteristics of study groups

From: Systematic review on the rational use of amniotic membrane allografts in diabetic foot ulcer treatment

 

Author

Year

Location (setting)

Study type

Study size

Mean age (years)/SD

Mean duration of DM

Ulcer location/s

Mean ulcer duration (days)/SD

Mean ulcer size (cm2)/SD

1

Thompson et al. [1]

2019

North Dakota

USA

RCT

13

(I = 7, C = 6)

I = 58.5(12.96)

C = 55.17(18.32

NA

Plantar

NA

I = 1.54(1.74)

C = 2.78(3.04)

2

Tettebach et al. [5]

2019

Multicenter

USA

RCT

110

(I = 54,C = 56)

I = 57.4(10.6)

C = 57.1(10.5)

NA

Toe, forefoot, midfoot and hindfoot

I = 145.6(129.5)

C = 149.8(110.6)

I = 3.2(2.8)

C = 3.9(3.8)

3

Didomenico et al. [9]

2016

Multicenter

USA

RCT

40

(I = 20, C = 20)

I-59.0(13)

C-58.0(9)

NA

Toe, forefoot, midfoot, heel, ankle, and hindfoot

 >  = 28.0

I = 2.0(0.90)

C = 3.3(4.35)

4

Snyder et al. [10]

2016

Multicenter

USA

RCT

29

(I = 15, C = 14)

I = 57.9(12.49)

C = 58.6(6.97)

NA

Forefoot, midfoot, hindfoot, pahanges, metatarsals

 >  = 28.0

I = 4.7(5.43)

C = 6.9(6.75)

5

Zelen et al

[11]

2015

Multicenter

USA

RCT

100

(I1 = 32, I2 = 33,

C = 35)

I1 = 63.3(12.25)

I2 = 63.8(11.86)

C = 60.6(11.55)

NA

Toe, forefoot, midfoot hindfoot, and ankle

I1 = 121.1(107.1)

I2 = 133.0(103.46)

C = 98.7(90.3)

I1 = 2.6(2.97)

I2 = 2.7(2.75)

C = 3.1(3.17)

6

Zelen et al. [12]

2014

Southwest Virginia USA

RCT

40

(I = 20,

C = 20)

I = 59.6(13.8)

C = 60.8(0.9)

NA

Toe, forefoot, midfoot and hindfoot

I = 118.3(151.9)

C = 122.5(101.5)

I = 2.4(1.8)

C = 2.0(1.3)

7

Lavery et al. [13]

2014

Multicenter

USA

RCT

97

(I = 50, C = 47)

I = 55.5(11.5)

C = 55.1(12.0)

I = 15.4(11.1)

C = 14.0(11.0)

Dorsal and plantar

I = 115.0(72.6)

C = 122.9(83.9)

I = 3.41(3.23)

C = 3.93(3.22)

8

Zelen et al. [2]

2013

Southwest Virginia

USA

RCT

25

(I = 13,

C = 12)

I = 56.4(14.7)

C = 61.7(10.3)

NA

Forefoot, digital, heel and midfoot

I = 98.7(91.0)

C = 114.8(108.5)

I = 2–6(1.9)

C = 3.4(2.9)

9

Valiente et al. [14]

2018

El Palmar

Spain

Prospective

Case series

N = 14

57

NA

Forefoot, midfoot and hind foot

 >  = 56

12.30

10

Abdo [15]

2016

St.Louis

USA

Prospective

Cases series

N = 14

56.7(9.1)

NA

Forefoot, midfoot and hindfoot

 >  = 28

6.5(11.6)

11

Raphael[16]

2016

Georgia

USA

Retrospective study

N = 29

52.9(1.83)

NA

Forefoot., midfoot and hindfoot

340.2(116.9)

10.6(2.15)

12

Kirsner et al. [17]

2015

Multicenter

USA

Retrospective study

N = 63

61.1(12.2)

NA

Planter

128.8

5.2

  1. SD standard deviation, DM diabetes mellitus, RCT randomized control trial, I intervention group, C control group, NA not available