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Table 1 Clinical features in 15 patients from the Sixth Affiliated Hospital and the Cancer Center of Sun Yat-sen University

From: Perianal and perineal rhabdomyosarcomas: a retrospective multicenter study of 35 cases

Gender/age

Presenting symptoms

Misdiagnosis/mistreatment

Time interval from symptom onset to pathological diagnosis

Tumor site

Maximum diameter of tumor (cm)

Treatment*

Pathological subtype

IRS clincial group/stage

outcome

Course of disease/survival time (m/m)

1/ < 10 y

Perianal mass

None

3 d

Perineal

6.6

LRR(R0) + Chemotherapy

ERMS

IV/T2bN1M1(lung, pleura, Mediastinum)

AWD

–/86

2/ ≥ 20 y

Perianal mass

None

1 m

Perineal

4.5

APR(R0) + Chemotherapy

ARMS

II/T2aN1M0

DOD

24/24

2/ ≥ 20 y

Perianal mass

None

1 m

Perineal

12.2

Chemotherapy

ERMS

III/T2bN1M0

DOD

18/18

2/10–19 y

Perianal mass

None

1 m

Perianal

6.8

Chemotherapy

ERMS

IV/T2bN1M1(bone; pelvic; retroperitoneum)

DOD

19/19

2/ ≥ 20 y

Painfulperianal mass

Perianal abscess/abscessotomy

2 m

Perianal

10.0

APR(Rx) + Chemotherapy

ARMS

II/T2bN1M0

DOD

8/8

2/ ≥ 20 y

Painful perianal mass

None

7 d

Perianal

4.7

APR(R0) + Chemotherapy

ARMS

I/T2aN0M0

AWD

12/12

2/10–19 y

Perianal mass

None

2 m

Perineal

5

Inguinal lymph node dissection + chemotherapy

ERMS

III/T2bN1M0

DOD

25/25

2/ ≥ 20 y

Perianal mass

Perianal abscess/

Intravenous antibiotics

2 m

Perianal

8

LRR(Rx) + Inguinal lymph node dissection + CRT

ARMS

II/T2bN1M0

NED

4/96

2/10–19 y

Perianal mass

None

5 m

Perianal

6.0

LRR(R0) + CRT

ERMS

II/T2bN0M0

NED

15/120

1/10–19 y

Perianal mass;;

difficult defecation

None

1 m

Perianal

1.8

Chemotherapy

ERMS

IV/T2aN1M1(bone)

DOD

11/11

2/ ≥ 20 y

Perianal mass

Perianal abscess/Abscessotomy + partial mass ectomy

4 m

Perianal

6.2

APR(R0) + Chemotherapy

ARMS

II/T2bN0M0

DOD

11/11

2/10–19 y

Painful perianal mass

Abscessotomy

2 m

Perianal

6.3

LRR(Rx) + CRT

ERMS

II/T2bN1M0

NED

10/24

2/10–19 y

Painful perianal mass;

Bloody stool

None

2 m

Perianal

7.5

Chemotherapy

ARMS

IV/T2bN1M1(breast; abdominopelvic)

DOD

11/11

2/10–19 y

Inguinal mass

None

3 m

Perineal

5.9

LRR(Rx) + abdominopelvic and inguinal lymph node dissection + CRT

ERMS

II/T2bN1M0

NED

12/12

2/ ≥ 20 y

Painful perianal mass

Abscessotomy

3 m

Perianal

10.0

Chemotherapy

ARMS

III/T2bN1M0

DOD

11/11

  1. y year, m month, d day, ARMS alveolar rhabdomyosarcoma, ERMS embryonal rhabdomyosarcoma, NED no evidence of disease, DOD died of disease, AWD alive with disease
  2. *LRR local radical resection, APR abdominoperineal resection, CRT chemoradiation therapy, R0 microscopic negative margins, R1 microscopic positive margins, Rx not evaluated