Table 3 Univariate and multivariate COX regression analyses for patients with isolated liver metastases
Features | Overall survival | Cancer specific survival | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age | ||||||||
< 60 | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
60–69 | 1.136 (0.920–1.402) | 0.236 | 1.171 (0.944–1.452) | 0.151 | 1.115 (0.900–1.382) | 0.318 | 1.149 (0.923–1.430) | 0.214 |
70–79 | 1.313 (1.062–1.623) | 0.012 | 1.155 (0.929–1.436) | 0.194 | 1.325 (1.069–1.641) | 0.010 | 1.165 (0.934–1.451) | 0.175 |
≥ 80 | 1.990 (1.580–2.505) | < 0.001 | 1.233 (0.960–1.583) | 0.101 | 1.966 (1.556–2.485) | < 0.001 | 1.216 (0.944–1.567) | 0.131 |
Gender | ||||||||
Male | 1.000 (Reference) | 1.000 (Reference) | ||||||
Female | 0.914 (0.775–1.078) | 0.286 | 0.934 (0.789–1.105) | 0.425 | ||||
Marriage | ||||||||
Married | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
Unmarried | 1.245 (1.066–1.455) | 0.006 | 1.006 (0.853–1.186) | 0.945 | 1.243 (1.061–1.455) | 0.007 | 1.003 (0.849–1.186) | 0.969 |
Unknown | 1.119 (0.751–1.668) | 0.579 | 1.057 (0.699–1.600) | 0.792 | 1.109 (0.738–1.664) | 0.619 | 1.039 (0.681–1.585) | 0.858 |
Race | ||||||||
White | 1.000 (Reference) | 1.000 (Reference) | ||||||
Black | 0.995 (0.804–1.232) | 0.964 | 0.993 (0.800–1.233) | 0.953 | ||||
Others | 0.939 (0.730–1.208) | 0.624 | 0.924 (0.714–1.195) | 0.545 | ||||
Grade | ||||||||
I | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
II | 1.240 (0.697–2.209) | 0.464 | 1.087 (0.604–1.957) | 0.781 | 1.202 (0.674–2.143) | 0.532 | 1.047 (0.581–1.887) | 0.879 |
III + IV | 1.982 (1.129–3.479) | 0.017 | 1.829 (1.035–3.233) | 0.038 | 1.917 (1.091–3.367) | 0.024 | 1.745 (0.986–3.088) | 0.056 |
Unknown | 2.396 (1.376–4.174) | 0.002 | 1.553 (0.861–2.800) | 0.143 | 2.324 (1.334–4.050) | 0.003 | 1.478 (0.818–2.669) | 0.195 |
T stage | ||||||||
T0 | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
T1 | 0.630 (0.288–1.376) | 0.247 | 0.683 (0.309–1.512) | 0.347 | 0.611 (0.279–1.337) | 0.217 | 0.666 (0.301–1.477) | 0.317 |
T2 | 0.374 (0.172–0.811) | 0.013 | 0.664 (0.296–1.490) | 0.321 | 0.364 (0.168–0.792) | 0.011 | 0.669 (0.298–1.503) | 0.331 |
T3 | 0.551 (0.260–1.168) | 0.120 | 0.666 (0.308–1.437) | 0.300 | 0.540 (0.255–1.145) | 0.108 | 0.659 (0.305–1.424) | 0.289 |
T4 | 0.573 (0.256–1.283) | 0.176 | 0.509 (0.224–1.153) | 0.105 | 0.574 (0.256–1.284) | 0.177 | 0.510 (0.225–1.157) | 0.107 |
TX | 0.713 (0.335–1.517) | 0.380 | 0.594 (0.277–1.274) | 0.181 | 0.678 (0.319–1.443) | 0.313 | 0.564 (0.263–1.210) | 0.142 |
N stage | ||||||||
N0 | 1.000 (Reference) | 1.000 (Reference) | ||||||
N1 | 0.907 (0.755–1.090) | 0.299 | 0.916 (0.760–1.103) | 0.353 | ||||
N2 | 1.102 (0.844–1.438) | 0.474 | 1.142 (0.874–1.492) | 0.329 | ||||
NX | 1.356 (1.094–1.682) | 0.005 | 1.359 (1.092–1.691) | 0.006 | ||||
Surgery at primary site | ||||||||
Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
No | 1.797 (1.528–2.112) | < 0.001 | 1.800 (1.401–2.313) | < 0.001 | 1.827 (1.550–2.154) | < 0.001 | 1.901 (1.474–2.453) | < 0.001 |
Radiation | ||||||||
Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
No | 1.879 (1.302–2.712) | 0.001 | 1.258 (0.861–1.838) | 0.236 | 1.8211.261–2.629) | 0.001 | 1.230 (0.841–1.798) | 0.286 |
Chemotherapy | ||||||||
Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
No | 2.600 (2.222–3.042) | < 0.001 | 2.700 (2.263–3.221) | < 0.001 | 2.599 (2.216–3.048) | < 0.001 | 2.723 (2.276–3.258) | < 0.001 |
Tumor size | ||||||||
< 3 cm | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
< 5 cm | 1.414 (1.051–1.902) | 0.022 | 1.326 (0.979–1.797) | 0.069 | 1.417 (1.050–1.913) | 0.023 | 1.321 (0.971–1.797) | 0.076 |
≥ 5 cm | 1.349 (1.021–1.783) | 0.035 | 1.269 (0.946–1.702) | 0.112 | 1.372 (1.036–1.818) | 0.027 | 1.279 (0.950–1.720) | 0.104 |
Unknown | 1.650 (1.300–2.095) | < 0.001 | 1.392 (1.079–1.795) | 0.011 | 1.623 (1.274–2.068) | 0.000 | 1.361 (1.051–1.762) | 0.019 |