Table 2 Univariate and multivariate COX regression analyses for metastatic gallbladder adenocarcinoma patients
Features | Overall survival | Cancer specific survival | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
Age | ||||||||
< 60 | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
60–69 | 1.045 (0.900–1.212) | 0.566 | 1.029 (0.885–1.195) | 0.711 | 1.023 (0.880–1.190) | 0.764 | 1.012 (0.869–1.178) | 0.879 |
70–79 | 1.243 (1.070–1.444) | 0.004 | 1.042 (0.894–1.215) | 0.599 | 1.221 (1.049–1.421) | 0.010 | 1.027 (0.879–1.200) | 0.736 |
≥ 80 | 1.774 (1.499–2.100) | < 0.001 | 1.167 (0.975–1.396) | 0.092 | 1.758 (1.482–2.085) | 0.000 | 1.156 (0.964–1.387) | 0.117 |
Gender | ||||||||
Male | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | |||||
Female | 0.878 (0.779–0.988) | 0.031 | 0.914 (0.809–1.033) | 0.151 | 0.897 (0.794–1.012) | 0.077 | ||
Marriage | ||||||||
Married | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
Unmarried | 1.204 (1.076–1.346) | 0.001 | 1.026 (0.910–1.155) | 0.679 | 1.206 (1.0761.352) | 0.001 | 1.012 (0.898–1.140) | 0.844 |
Unknown | 1.166 (0.870–1.563) | 0.304 | 0.874 (0.647–1.180) | 0.380 | 1.180 (0.878–1.587) | 0.273 | 0.880 (0.650–1.192) | 0.411 |
Race | ||||||||
White | 1.000 (Reference) | 1.000 (Reference) | ||||||
Black | 1.033 (0.883–1.209) | 0.683 | 1.031 (0.879–1.208) | 0.711 | ||||
Others | 1.050 (0.879–1.254) | 0.589 | 1.043 (0.871–1.250) | 0.645 | ||||
Grade | ||||||||
I | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
II | 1.087 (0.770–1.535) | 0.636 | 1.173 (0.828–1.662) | 0.368 | 1.046 (0.740–1.478) | 0.800 | 1.119 (0.789–1.587) | 0.527 |
III + IV | 1.643 (1.174–2.298) | 0.004 | 1.704 (1.212–2.397) | 0.002 | 1.582 (1.130–2.214) | 0.008 | 1.639 (1.165–2.307) | 0.005 |
Unknown | 1.893 (1.364–2.627) | < 0.001 | 1.489 (1.046–2.120) | 0.027 | 1.845 (1.329–2.560) | < 0.001 | 1.455 (1.021–2.073) | 0.038 |
T stage | ||||||||
T0 | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
T1 | 1.048 (0.644–1.704) | 0.851 | 1.349 (0.823–2.211) | 0.235 | 1.009 (0.620–1.643) | 0.971 | 1.273 (0.776–2.088) | 0.339 |
T2 | 0.590 (0.365–0.952) | 0.031 | 1.027 (0.621–1.699) | 0.917 | 0.568 (0.351–0.918) | 0.021 | 0.982 (0.593–1.626) | 0.943 |
T3 | 0.877 (0.555–1.386) | 0.574 | 1.082 (0.678–1.725) | 0.741 | 0.849 (0.537–1.341) | 0.483 | 1.034 (0.648–1.649) | 0.889 |
T4 | 0.869 (0.528–1.431) | 0.581 | 0.948 (0.573–1.568) | 0.835 | 0.858 (0.521–1.414) | 0.548 | 0.926 (0.560–1.532) | 0.764 |
TX | 1.087 (0.685–1.725) | 0.725 | 1.077 (0.677–1.714) | 0.755 | 1.048 (0.660–1.664) | 0.843 | 1.027 (0.645–1.635) | 0.911 |
N stage | ||||||||
N0 | 1.000 (Reference) | 1.000 (Reference) | ||||||
N1 | 0.937 (0.820–1.070) | 0.336 | 0.938 (0.819–1.074) | 0.352 | ||||
N2 | 0.985 (0.827–1.173) | 0.863 | 1.005 (0.842–1.198) | 0.958 | ||||
NX | 1.359 (1.156–1.597) | < 0.001 | 1.352 (1.147–1.594) | < 0.001 | ||||
Surgery at primary site | ||||||||
Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
No | 1.633 (1.452–1.836) | < 0.001 | 1.578 (1.329–1.873) | < 0.001 | 1.641 (1.456–1.849) | < 0.001 | 1.588 (1.334–1.890) | < 0.001 |
Radiation | ||||||||
Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
No | 1.482 (1.188–1.849) | < 0.001 | 1.125 (0.8981.409) | 0.307 | 1.454 (1.163–1.817) | 0.001 | 1.107 (0.882–1.388) | 0.380 |
Chemotherapy | ||||||||
Yes | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
No | 2.554 (2.282–2.858) | < 0.001 | 2.711 (2.3973.066) | < 0.001 | 2.556 (2.280–2.865) | < 0.001 | 2.723 (2.404–3.086) | < 0.001 |
Metastatic type | ||||||||
Single site | 1.000 (Reference) | 1.000 (Reference) | ||||||
Multiple sites | 1.001 (0.894–1.120) | 0.990 | 0.933 | 0.995 (0.888–1.116) | 0.933 | |||
Tumor size | ||||||||
< 3 cm | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | 1.000 (Reference) | ||||
< 5 cm | 1.373 (1.109–1.700) | 0.004 | 1.340 (1.076–1.668) | 0.009 | 1.372 (1.106–1.703) | 0.004 | 1.330 (1.066–1.659) | 0.012 |
≥ 5 cm | 1.420 (1.164–1.731) | 0.001 | 1.354 (1.101–1.666) | 0.004 | 1.391 (1.138–1.701) | 0.001 | 1.327 (1.076–1.636) | 0.008 |
Unknown | 1.657 (1.399–1.961) | < 0.001 | 1.387 (1.158–1.661) | < 0.001 | 1.630 (1.374–1.933) | < 0.001 | 1.356 (1.130–1.627) | 0.001 |