Table 3 Univariate and multivariate analysis of overall survival (training cohort, n = 248)

AGLR level (> 90 vs ≤ 90)

2.66 (2.01–3.88)

 < 0.001

1.79 (1.21–2.69)

 < 0.001

Age, years (> 60 vs ≤ 60)

1.24 (0.81–1.83)

0.308

Gender (male vs female)

1.23 (0.72–1.91)

0.441

Drinking (yes vs no)

1.03 (0.74–1.41)

0.862

HBsAg (positive vs negative)

1.29 (0.78–2.06)

0.303

AFP, ng/ml (> 20 vs ≤ 20)

1.71 (1.19–2.47)

0.003

1.13 (0.77–1.67)

0.514

Liver cirrhosis (yes vs no)

1.03 (0.51–2.09)

0.930

Tumor size, cm (> 5 vs ≤ 5)

2.86 (1.97–3.91)

 < 0.001

1.91 (1.27–2.61)

 < 0.001

Tumor number (multiple vs single)

1.60 (1.13–2.26)

0.006

1.12 (0.81–1.53)

0.460

TNM stage (III–IV vs I–II)

1.96 (1.39–2.77)

 < 0.001

1.52 (1.03–2.31)

0.025

MVI (yes vs no)

2.57 (1.93–3.74)

 < 0.001

1.61 (1.23–2.39)

0.007

Recurrence (yes vs no)

2.70 (1.69–3.59)

 < 0.001

2.01 (1.47–2.83)

 < 0.001