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Table 1 Characteristics of the included studies and participants studies

From: Interventions to prevent anastomotic leak after esophageal surgery: a systematic review and meta-analysis

First author (year)

Country

Total participants (N)

Total participants in intervention groups (n)

Prevalence AL (%)

Male-to-female ratio evaluated

(T, I, C)

Age, years (y)

Mean ± SD

Neoadjuvant therapy

Follow-up, months (mo, wk, or y)

Mean ± SD

Bhat 2006 [6]

India

194

97

8.8

T: 3:1.8

T: 52.5

Excluded patients with previous neoadjuvant Tx

F/U every 3-mo for 3 y postop every 4- to 6-mo postop

Dai 2011 [5]

China

253

127

3.1

T: 4:01

T: 63.5

Excluded patients with previous neoadjuvant Tx

*22 mo (3–52 mo)

Daryaei 2008 [19]

Iran

40

18

15

NR

T: 58.4 ± 10.3

NP

NP

Gupta 2001 [20]

India

100

48

12

I: 0.8:1

C: 0.7:1

I: 51.3 ± 13.0

C: 50.8 ± 13.2

Rad ± Chemo: 22/100 and Chemo alone: 56/100

3 mo or more

Hayashi 2019 [21]

Japan

71

34

5.6

T: 6:8

T: 63.04

NP

NP

Law 1997 [22]

Hong Kong

122

61

3.3

I: 7.7:1

C: 6.6:1

I: 64 ± 1.2

C: 63 ± 1.0

NP

20 (SD 2.2) mo hand-sewn and 19 (2.2) mo stapled group (p = NS)

Liu 2014 [7]

China

378

188

4.2

T: 3:01

T: 64

Excluded patients with previous neoadjuvant Tx

NP

Liu 2015 [23]

China

432

219

5

I: 3:1

C: 3:1

I: 62 ± 8

C: 61 ± 9

Rad + chemo: 64/478

17.8 (3.2) mo hand-sewn and 18.3 (3.4) mo stapled

Luechakiettisak 2008 [24]

Thailand

104

52

4.8

I: 4.8:1

C: 5.6:1

I: 63.6

C: 62.0

NP

NP

Mistry 2012 [25]

India

253

127

3.1

T: 2.1:1

I: 53.4

C: 56.7

Rad ± Chemo: 2/150 and Chemo alone: 72/150

NP

Nederlof 2011 [26]

Netherlands

128

64

31

I: 2:1

C: 7:1

I: 60

C: 63

Rad + Chemo: 27/64 and Chemo alone: 17/64

3- or 6-wk outpatient visit. 3 mo first y postop. Every 4 mo second y postop

Okuyama 2007 [27]

Japan

32

14

12

I: 13:1

C: 16:2

I: 63.6

C: 64.3

Excluded patients with previous neoadjuvant Tx

5 y

Saluja 2012 [28]

India

174

87

17

I: 2.3:1

C: 1.6:1

I: 51.4 ± 12

C:50.9 ± 14

Rad + Chemo: 107/174

NP

Zhang 2010 [29]

China

516

272

1.4

I: 1.4:1

C: 1.4:1

I: 59 ± 1.2

C: 60 ± 1.3

Excluded patients with previous neoadjuvant Tx

12 mo

Zheng 2013 [4]

China

164

82

8.5

I: 1.6:1

C: 1.4:1

I: 67.5 ± 11.2

C: 65.7 ± 9.4

None of the patients received chemotherapy or radiotherapy pre-op

3 y

Tabira 2004 [30]

Japan

44

22

14

I: 6.3:1

C: 10:1

I: 64 ± 8

C: 60 ± 8

NP

NP

Valverde 1996 [31]

France

152

78

16

I: 9.6:1

C: 10.1:1

I: 59 ± 9

C: 59 ± 10

NP

NP

  1. C control, Chemo chemotherapy, I intervention, mo months, NP not provided, pre-op pre-operatively, postop postoperatively, Rad radiation, SD standard deviation, Tx therapy, wk weeks, Y years
  2. *Median (range)