Fig. 3

Receiver operating characteristic (ROC) curves of multivariate logistic regression of WBCC 4th POD (a), CRP 4th POD (b), ΔCRP 2nd–4th POD (c), NUn score (d), non-neoadjuvant CRP 4th (e), and 5th POD (f) for predicting anastomotic leakage after esophageal resection. True positive rate (sensitivity) is plotted in function of false-positive rate (100-specificity). The closer the graph to the upper left corner, the better the diagnostic accuracy. The area under the ROC curve (AUROCC) indicates the performance of the values for determining anastomotic leakage after esophageal resection. The AUC of WBCC 4th POD is 0.67 (p = 0.0005); CRP 4th POD, 0.65 (p < 0.0001); ΔCRP 2nd–4th POD, 0.62 (p = 0.0003); NUn score, 0.68 (p = 0.004); and non-neoadjuvant CRP 4th POD, 0.68 (p = 0.01) and 5th POD, 0.67 (p = 0.0009)