Table 1 Repetitive measurements of selected laboratory parameters in all patients during the follow-up

CRP (mg/l)

6.81 (3.7–11.1)

5.28 (2.8–10.1)

5.7 (2.6–10.1)

5.91 (1.98–13.85)

2.4 (0.8–6.2)

5.2 (1–8-9.3)

 < 0.001

FPG (mg/dl)

106 (98–122)

101 (92–111.5)

98 (89–105)

98 (90–108)

93 (87–100)

93 (87–101)

 < 0.001

Insulin (mIU/l)

22.1 (14.6–32.35)

11.8 (7.95–16.3)

10.65 (7.4–14.8)

8.5 (5.3–15.1)

8.3 (6.1–11.9)

12.8 (8–17.4)

 < 0.001

HOMA-IR

5.85 (3.61–9.81)

2.74 (1.79–3.81)

2.31 (1.51–3.32)

1.78 (1.07–3.47)

1.65 (1.21–2.53)

2.63 (1.7–3.78)

 < 0.001

ALT (IU/l)

33 (22.95–47)

35 (24.5–47.1)

24 (18–32.8)

19.2 (14–27)

20.25 (15.8–27)

19 (14–23)

 < 0.001

AST (IU/l)

26 (19.25–38.6)

27 (21–36)

22 (17–28.3)

19 (15.2–26)

20.55 (16.1–25)

19 (16–23.8)

 < 0.001

Cholesterol (mg/dl)

204.00 (176–230)

174 (154–198)

178 (157–200)

196 (173–222)

179 (163–205)

187 (166–209)

 < 0.001

LDL (mg/dl)

138.00 (113–116)

116 (97–141)

120 (98–141)

131 (106.1–154)

118.25 (99–138.7)

115 (98–131)

 < 0.001

TG (mg/dl)

156 (112–198)

133 (104–171)

123 (96–151)

49 (39–60)

93 (73–126)

122 (93–143)

 < 0.001

HDL (mg/dl)

46 (38–58)

37 (31–44)

43 (36–49)

49 (39–60)

55 (47–64)

53 (47–63)

 < 0.001