Preoperative risk grade predicts the long-term prognosis of intrahepatic cholangiocarcinoma: a retrospective cohort analysis

Table 4 The independent prognostic predictors for ICC

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p	HR	95% CI	p
ALT (≧ 40 v < 40 U)	1.366	1.053–1.772	0.019	1.221	0.932–1.600	0.148
CEA (≧ 5 v < 5 U)	1.857	1.372–2.513	< 0.001	1.449	1.049–2.000	0.024
CA19-9 (≧ 37 v < 37 U)	1.619	1.226–2.137	0.001	1.454	1.090–1.940	0.011
Tumor number (multiple v single)	1.969	1.457–2.660	< 0.001	2.529	1.849–3.460	< 0.001
VI (yes v no)	2.053	1.534–2.747	< 0.001	1.402	1.036–1.897	0.029
Lymph node metastasis (yes v no)	2.227	1.714–2.894	< 0.001	1.720	1.302–2.274	< 0.001
PRG
0	Reference			Reference
1	3.969	2.316–6.799	< 0.001	3.800	2.203–6.555	< 0.001
2	8.617	5.038–14.739	< 0.001	7.585	4.357–13.206	< 0.001

ICC intrahepatic cholangiocarcinoma, ALT alanine aminotransferase, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, VI vascular invasion, PRG preoperative risk grade

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