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Table 3 The relationship between the preoperative risk grade and the clinicopathological characteristics

From: Preoperative risk grade predicts the long-term prognosis of intrahepatic cholangiocarcinoma: a retrospective cohort analysis

Variables

Preoperative risk grade

p

0

n = 84

1

n = 196

2

n = 188

Age

58 (50–65)

59 (52–64)

58 (50–66)

0.623

Gender (male)

50 (59.5%)

112 (57.1%)

120 (63.8%)

0.404

Smoking (yes v no)

32 (38.1%)

54 (27.6%)

46 (24.5)

0.067

Drinking (yes)

16 (19.0%)

30 (15.3%)

20 (10.6)

0.150

HBsAg (positive)

46 (54.8%)

92 (46.9%)

64 (34.0%)

0.002

ALT (U/L)

21 (15–37)

29 (16–65)

36 (17–88)

< 0.001

ALB (g/L)

38.5 (35.6.2–41.3)

34.1 (33.2–38.2)

30.7 (29.20–34.6)

< 0.001

TBIL (μmol/L)

11.6 (8.7–15.4)

13.9 (9.1–22.5)

13.4 (8.9–82.5)

< 0.001

Child–Pugh grade (B)

4 (4.8%)

52 (26.5%)

70 (37.2%)

< 0.001

Cirrhosis (yes)

42 (50.0%)

82 (41.8%)

98 (52.1%)

0.114

LMR

4.4 (3.1–5.4)

3.4 (1.8–4.4)

2.6 (1.3–3.5)

< 0.001

NLR

1.97 (1.38–2.51)

2.3 (1.6–3.3)

3.1 (2.2–5.2)

< 0.001

PLR

87.4 (75.7–115.8)

127.7 (94.0–197.8)

234.7 (185.2–274.5)

< 0.001

Log10 AFP

0.66 (0.44–1.84)

0.51 (0.32–0.72)

0.51 (0.35–1.09)

0.020

Log10 CEA

0.29 (0.10–0.45)

0.49 (0.25–0.61)

0.49 (0.33–0.70)

< 0.001

Log10 CA19-9

1.56 (1.05–2.33)

1.91 (1.34–2.77)

2.21 (1.45–2.97)

< 0.001

Tumor number (multiple)

20 (23.8%)

42 (21.4%)

45 (23.9%)

0.821

Tumor diameter (> 5 cm)

50 (59.5%)

90 (45.9%)

68 (36.2%)

0.001

VI (yes)

6 (7.1%)

40 (20.4%)

54 (28.7%)

< 0.001

Lymph node metastasis (yes)

16 (19.0%)

54 (27.6%)

88 (46.8%)

< 0.001

Tumor differentiation

   

0.989

 Well

6 (7.1%)

16 (8.2%)

14 (7.4%)

 

 Moderate

62 (73.8%)

146 (74.5%)

138 (73.4%)

 

 Poor

16 (19.0%)

34 (17.3%)

36 (19.1%)

 

Adjuvant chemotherapy (yes)

22 (26.2%)

38 (19.4%)

30 (16.0%)

0.141

Type of hepatectomy (major)

48 (57.1%)

106 (54.1%)

102 (54.3%)

0.884

Blood transfusion (yes)

16 (19.0%)

58 (29.6%)

60 (31.9%)

0.088

  1. HBsAg hepatitis B surface antigen, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, LMR lymphocyte to monocyte ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, AFP α-fetoprotein, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, VI vascular invasion