Preoperative risk grade predicts the long-term prognosis of intrahepatic cholangiocarcinoma: a retrospective cohort analysis

Table 2 Factors associated with the OS of ICC

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	p	HR	95% CI	p
Age	0.988	0.977–1.00	0.051
Gender (male v female)	0.909	0.701–1.118	0.474
Smoking (yes v no)	0.886	0.664–1.181	0.409
Drinking (yes v no)	1.161	0.807–1.671	0.421
HBsAg (positive v negative)	0.942	0.726–1.222	0.654
ALT (U/L)	1.001	1.000–1.003	0.037	1.001	0.997–1.002	0.440
ALB (g/L)	0.921	0.898–0.945	< 0.001	0.947	0.920–0.975	< 0.001
TBIL (μmol/L)	1.001	0.999–1.003	0.183
Child–Pugh grade (B v A)	1.031	0.771–1.379	0.835
Cirrhosis (yes v no)	1.202	0.930–1.553	0.161
LMR	0.996	0.989–1.003	0.302
NLR	1.005	0.975–1.037	0.733
PLR	1.011	1.009–1.012	< 0.001	1.008	1.006–1.010	< 0.001
Log₁₀ AFP	1.322	0.905–1.911	0.135
Log₁₀ CEA	1.678	1.345–2.093	< 0.001	1.013	0.755–1.359	0.933
Log₁₀ CA19-9	1.615	1.428–1.827	< 0.001	1.475	1.278–1.703	< 0.001
Tumor number (multiple v single)	1.969	1.457–2.660	< 0.001	2.234	1.623–3.074	< 0.001
Tumor diameter (> 5 v ≤ 5 cm)	0.972	0.750–1.259	0.830
VI (yes v no)	2.053	1.534–2.747	< 0.001	1.361	0.997–1.856	0.052
Lymph node metastasis (yes v no)	2.227	1.714–2.894	< 0.001	1.344	1.013–1.784	0.040
Tumor differentiation
Well	Reference
Moderate	1.016	0.598–1.725	0.954
Poor	0.938	0.590–1.491	0.786
Adjuvant chemotherapy (yes v no)	0.876	0.635–1.210	0.422
Type of hepatectomy (major v minor)	1.058	0.818–1.369	0.668
Blood transfusion (yes v no)	1.101	0.828–1.464	0.507

OS overall survival rate, ICC intrahepatic cholangiocarcinoma, HBsAg hepatitis B surface antigen, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, LMR lymphocyte to monocyte ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, AFP α-fetoprotein, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, VI vascular invasion

ISSN: 1471-2482