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Table 2 Factors associated with the OS of ICC

From: Preoperative risk grade predicts the long-term prognosis of intrahepatic cholangiocarcinoma: a retrospective cohort analysis

Variables Univariate analysis Multivariate analysis
HR 95% CI p HR 95% CI p
Age 0.988 0.977–1.00 0.051    
Gender (male v female) 0.909 0.701–1.118 0.474    
Smoking (yes v no) 0.886 0.664–1.181 0.409    
Drinking (yes v no) 1.161 0.807–1.671 0.421    
HBsAg (positive v negative) 0.942 0.726–1.222 0.654    
ALT (U/L) 1.001 1.000–1.003 0.037 1.001 0.997–1.002 0.440
ALB (g/L) 0.921 0.898–0.945 < 0.001 0.947 0.920–0.975 < 0.001
TBIL (μmol/L) 1.001 0.999–1.003 0.183    
Child–Pugh grade (B v A) 1.031 0.771–1.379 0.835    
Cirrhosis (yes v no) 1.202 0.930–1.553 0.161    
LMR 0.996 0.989–1.003 0.302    
NLR 1.005 0.975–1.037 0.733    
PLR 1.011 1.009–1.012 < 0.001 1.008 1.006–1.010 < 0.001
Log10 AFP 1.322 0.905–1.911 0.135    
Log10 CEA 1.678 1.345–2.093 < 0.001 1.013 0.755–1.359 0.933
Log10 CA19-9 1.615 1.428–1.827 < 0.001 1.475 1.278–1.703 < 0.001
Tumor number (multiple v single) 1.969 1.457–2.660 < 0.001 2.234 1.623–3.074 < 0.001
Tumor diameter (> 5 v ≤ 5 cm) 0.972 0.750–1.259 0.830    
VI (yes v no) 2.053 1.534–2.747 < 0.001 1.361 0.997–1.856 0.052
Lymph node metastasis (yes v no) 2.227 1.714–2.894 < 0.001 1.344 1.013–1.784 0.040
Tumor differentiation       
 Well Reference      
 Moderate 1.016 0.598–1.725 0.954    
 Poor 0.938 0.590–1.491 0.786    
Adjuvant chemotherapy (yes v no) 0.876 0.635–1.210 0.422    
Type of hepatectomy (major v minor) 1.058 0.818–1.369 0.668    
Blood transfusion (yes v no) 1.101 0.828–1.464 0.507    
  1. OS overall survival rate, ICC intrahepatic cholangiocarcinoma, HBsAg hepatitis B surface antigen, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, LMR lymphocyte to monocyte ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, AFP α-fetoprotein, CEA carcinoembryonic antigen, CA19-9 carbohydrate antigen 19-9, VI vascular invasion