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Table 7 Uni- and multivariate analysis to identify preoperative prognostic factors associated with overall survival in the 36 patients with LHL15 < 0.9

From: Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function

Variables Univariate analysis Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
Age 1.005 (0.95–1.07) 0.87   
Female 0.59 (0.38–7.52) 0.49   
BMI 0.93 (0.82–1.06) 0.29   
Lymphocyte count (/mm3) 1.0 (1.00–1.00) 0.69   
Neutrophil count (/mm3) 1.0 (1.00–1.00) 0.73   
Platelet count (103/µl) 1.0 (0.97–1.03) 0.90   
Albumin (g/dl) 0.52 (0.21–1.28) 0.16   
Total bilirubin (mg/dl) 1.12 (0.46–2.70) 0.81   
PT-INR 9.01 (0.18–461.3) 0.27   
Child–Pugh B 1.86 (0.49–7.04) 0.36   
AFP (ng/ml) 1.0 (1.00–1.00) 0.33   
DCP (mAU/ml) 1.0 (1.00–1.00) 0.01 1.0 (1.00–1.00) 0.005
ICG R15 (%) 1.03 (0.98–1.07) 0.22   
LHL15 7.68 (0.00–135,931) 0.68   
Tumor size (cm) 1.11 (0.98–1.26) 0.12   
Multiple tumor 2.82 (0.97–8.20) 0.058 3.27 (1.09–9.90) 0.035
Milan criteria beyond 1.52 (0.52–4.46) 0.45   
PNI 0.95 (0.88–1.02) 0.15   
NLR 1.05 (0.93–1.20) 0.44   
PLR 1.0 (1.00–1.00) 0.59   
ALBI score 1.72 (0.72–4.13) 0.23   
  1. Differences were considered significant at p < 0.05, shown as italic values
  2. BMI body mass index, PNI prognostic nutritional index, PT-INR prothrombin time-international normalized ratio, AFP alpha fetoprotein, DCP des-γ-carboxyprothrombin, ICGR15 indocyanine green retention rate at 15 min, LHL15 GSA uptake ratio of the liver to the liver plus heart at 15 min, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, ALBI score albumin-bilirubin score