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Table 6 Uni- and Multivariate analysis to identify preoperative prognostic factors associated with overall survival in the 153 patients with LHL15 ≥ 0.9

From: Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function

Variables Univariate analysis Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
Age 1.018 (0.98–1.06) 0.40   
Female 0.4 (0.05–0.93) 0.04 0.15 (0.034–0.65) 0.011
BMI 1.0 (0.90–1.12) 0.39   
Lymphocyte count (/mm3) 1.0 (1.00–1.00) 0.26   
Neutrophil count (/mm3) 1.0 (1.00–1.00) 0.37   
Platelet count (103/µl) 1.0 (0.99–1.03) 0.63   
Albumin (g/dl) 0.42 (0.20–0.86) 0.017   
Total bilirubin (mg/dl) 0.76 (0.33–1.79) 0.054   
PT-INR 4.30 (0.35–53.19) 0.26   
Child–Pugh B 1.87 (0.74–4.72) 0.18   
AFP (ng/ml) 1.0 (1.00–1.00) 0.80   
DCP (mAU/ml) 1.0 (1.00–1.00) 0.28   
ICG R15 (%) 1.03 (1.01–1.05) 0.008   
LHL15 0.52 (0.00–6.69) 0.23   
Tumor size (cm) 1.13 (1.07–1.18)  < 0.001 1.13 (1.06–1.21)  < 0.001
Multiple tumor 1.30 (0.69–2.43) 0.41   
Milan criteria beyond 2.25 (1.26–4.00) 0.006   
PNI 0.94 (0.90–0.98) 0.003 0.92 (0.87–0.97) 0.005
NLR 1.08 (0.98–1.20) 0.12   
PLR 1.0 (1.00–1.00) 0.58   
ALBI score 2.08 (1.19–3.63) 0.01   
  1. Differences were considered significant at p < 0.05, shown as italic values
  2. BMI body mass index, PNI prognostic nutritional index, PT-INR prothrombin time-international normalized ratio, AFP alpha fetoprotein, DCP des-γ-carboxyprothrombin, ICGR15 indocyanine green retention rate at 15 min, LHL15 GSA uptake ratio of the liver to the liver plus heart at 15 min, NLR: neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, ALBI score albumin-bilirubin score