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Table 1 Univariate and multivariate analysis of prognostic factors in patients with gastric cancer

From: Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection

Clinicopathological feature

Univariate analysis

Multivariate analysis

HR

95% CI

p value

HR

95% CI

p value

Age (years)

 ≤ 60

1

  

1

  

 > 60

1.62

1.16–2.25

0.005

1.63

1.15–2.31

0.007

Gender

 Male

1

     

 Female

1.01

0.73–1.40

0.967

   

BMI

 ≤ 24 kg/m2

1

     

 > 24 kg/m2

0.77

0.52–1.13

0.175

   

Tumor location

 Upper third

1

     

 Middle third

0.53

0.29–0.98

0.041

   

 Lower third

0.47

0.31–0.71

< 0.001

   

 Two-thirds or more

0.76

0.27–2.15

0.600

   

Gastrectomy

 Distal

1

     

 Total

1.57

1.10–2.23

0.013

   

 Proximal

NA

     

Tumor size

 ≤ 5 cm

1

     

 > 5 cm

2.60

1.90–3.54

< 0.001

   

Histologic type

 Differentiated

1

     

 Undifferentiated

1.29

0.95–1.76

0.106

   

Perineural invasion

 Absence

1

     

 Presence

2.73

2.00–3.72

< 0.001

   

Lymphovascular invasion

 Absence

1

     

 Presence

2.78

2.02–3.83

< 0.001

   

T category

 T1

1

  

1

  

 T2

4.30

1.56–11.83

0.005

3.04

1.08–8.57

0.036

 T3

2.04

0.25–16.92

0.510

1.69

0.20–14.50

0.633

 T4a

15.79

6.97–35.76

< 0.001

8.22

3.26–20.75

< 0.001

 T4b

28.21

9.78–81.36

< 0.001

13.05

3.98–42.82

< 0.001

N category

 N0

1

  

1

  

 N1

3.22

1.76–5.90

< 0.001

1.70

0.88–3.26

0.112

 N2

4.71

2.75–8.05

< 0.001

2.09

1.15–3.81

0.016

 N3a

11.35

6.82–18.89

< 0.001

5.38

3.00–9.65

< 0.001

 N3b

24.19

13.27–44.07

< 0.001

11.01

5.50–22.04

< 0.001

Chemotherapy

 No

1

  

1

  

 Yes

1.58

1.12–2.22

0.009

0.70

0.48–1.01

0.059

Number of lymph nodes retrieved

 ≤ 15

1

  

1

  

 16–29

0.75

0.50–1.13

0.169

0.46

0.30–0.70

< 0.001

 ≥ 30

1.36

0.88–2.11

0.166

0.52

0.32–0.84

0.008

PI

 0

1

     

 1

1.54

0.96–2.49

0.075

   

PNI

 < 49.5

1

     

 ≥ 49.5

0.40

0.27–0.59

< 0.001

   

Fibrinogen

 < 397 ng/dl

1

     

 ≥ 397 ng/dl

2.06

1.51–2.81

< 0.001

   

NLR

 < 2.5

1

  

1

  

 ≥ 2.5

1.69

1.24–2.31

0.001

0.70

0.48–1.01

0.059

PLR

 < 154

1

  

1

  

 ≥ 154

2.21

1.62–3.01

< 0.001

1.70

1.20–2.42

0.003

SII

 < 556

1

     

 ≥ 556

1.94

1.43–2.64

< 0.001

   

GPS

 0

1

     

 1

1.76

1.24–2.49

0.002

   

 2

1.89

1.04–3.43

0.037

   

mGPS

 0

1

     

 1

1.53

0.68–3.46

0.307

   

 2

1.66

0.92–3.00

0.091

   

CRP/Alb

 < 0.05

1

     

 ≥ 0.05

1.91

1.40–2.60

< 0.001

   

CEA

 ≤ 5 ng/mL

1

     

 > 5 ng/mL

1.76

1.16–2.68

0.008

   
  1. HR Hazard ratios, CI Confidence interval, BMI Body mass index, PNI Prognostic nutritional index, PI Prognostic index, GPS Glasgow Prognostic Score, mGPS Modified Glasgow Prognostic Score, NLR Neutrophil-lymphocyte ratio, PLR Platelet-lymphocyte ratio, CRP/Alb C-reactive protein/albumin, SII Systemic immune-inflammatory index
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