|
Clinicopathological feature
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
HR
|
95% CI
|
p value
|
HR
|
95% CI
|
p value
|
|---|
|
Age (years)
|
|
≤ 60
|
1
| | |
1
| | |
|
> 60
|
1.62
|
1.16–2.25
|
0.005
|
1.63
|
1.15–2.31
|
0.007
|
|
Gender
|
|
Male
|
1
| | | | | |
|
Female
|
1.01
|
0.73–1.40
|
0.967
| | | |
|
BMI
|
|
≤ 24 kg/m2
|
1
| | | | | |
|
> 24 kg/m2
|
0.77
|
0.52–1.13
|
0.175
| | | |
|
Tumor location
|
|
Upper third
|
1
| | | | | |
|
Middle third
|
0.53
|
0.29–0.98
|
0.041
| | | |
|
Lower third
|
0.47
|
0.31–0.71
|
< 0.001
| | | |
|
Two-thirds or more
|
0.76
|
0.27–2.15
|
0.600
| | | |
|
Gastrectomy
|
|
Distal
|
1
| | | | | |
|
Total
|
1.57
|
1.10–2.23
|
0.013
| | | |
|
Proximal
|
NA
| | | | | |
|
Tumor size
|
|
≤ 5 cm
|
1
| | | | | |
|
> 5 cm
|
2.60
|
1.90–3.54
|
< 0.001
| | | |
|
Histologic type
|
|
Differentiated
|
1
| | | | | |
|
Undifferentiated
|
1.29
|
0.95–1.76
|
0.106
| | | |
|
Perineural invasion
|
|
Absence
|
1
| | | | | |
|
Presence
|
2.73
|
2.00–3.72
|
< 0.001
| | | |
|
Lymphovascular invasion
|
|
Absence
|
1
| | | | | |
|
Presence
|
2.78
|
2.02–3.83
|
< 0.001
| | | |
|
T category
|
|
T1
|
1
| | |
1
| | |
|
T2
|
4.30
|
1.56–11.83
|
0.005
|
3.04
|
1.08–8.57
|
0.036
|
|
T3
|
2.04
|
0.25–16.92
|
0.510
|
1.69
|
0.20–14.50
|
0.633
|
|
T4a
|
15.79
|
6.97–35.76
|
< 0.001
|
8.22
|
3.26–20.75
|
< 0.001
|
|
T4b
|
28.21
|
9.78–81.36
|
< 0.001
|
13.05
|
3.98–42.82
|
< 0.001
|
|
N category
|
|
N0
|
1
| | |
1
| | |
|
N1
|
3.22
|
1.76–5.90
|
< 0.001
|
1.70
|
0.88–3.26
|
0.112
|
|
N2
|
4.71
|
2.75–8.05
|
< 0.001
|
2.09
|
1.15–3.81
|
0.016
|
|
N3a
|
11.35
|
6.82–18.89
|
< 0.001
|
5.38
|
3.00–9.65
|
< 0.001
|
|
N3b
|
24.19
|
13.27–44.07
|
< 0.001
|
11.01
|
5.50–22.04
|
< 0.001
|
|
Chemotherapy
|
|
No
|
1
| | |
1
| | |
|
Yes
|
1.58
|
1.12–2.22
|
0.009
|
0.70
|
0.48–1.01
|
0.059
|
|
Number of lymph nodes retrieved
|
|
≤ 15
|
1
| | |
1
| | |
|
16–29
|
0.75
|
0.50–1.13
|
0.169
|
0.46
|
0.30–0.70
|
< 0.001
|
|
≥ 30
|
1.36
|
0.88–2.11
|
0.166
|
0.52
|
0.32–0.84
|
0.008
|
|
PI
|
|
0
|
1
| | | | | |
|
1
|
1.54
|
0.96–2.49
|
0.075
| | | |
|
PNI
|
|
< 49.5
|
1
| | | | | |
|
≥ 49.5
|
0.40
|
0.27–0.59
|
< 0.001
| | | |
|
Fibrinogen
|
|
< 397 ng/dl
|
1
| | | | | |
|
≥ 397 ng/dl
|
2.06
|
1.51–2.81
|
< 0.001
| | | |
|
NLR
|
|
< 2.5
|
1
| | |
1
| | |
|
≥ 2.5
|
1.69
|
1.24–2.31
|
0.001
|
0.70
|
0.48–1.01
|
0.059
|
|
PLR
|
|
< 154
|
1
| | |
1
| | |
|
≥ 154
|
2.21
|
1.62–3.01
|
< 0.001
|
1.70
|
1.20–2.42
|
0.003
|
|
SII
|
|
< 556
|
1
| | | | | |
|
≥ 556
|
1.94
|
1.43–2.64
|
< 0.001
| | | |
|
GPS
|
|
0
|
1
| | | | | |
|
1
|
1.76
|
1.24–2.49
|
0.002
| | | |
|
2
|
1.89
|
1.04–3.43
|
0.037
| | | |
|
mGPS
|
|
0
|
1
| | | | | |
|
1
|
1.53
|
0.68–3.46
|
0.307
| | | |
|
2
|
1.66
|
0.92–3.00
|
0.091
| | | |
|
CRP/Alb
|
|
< 0.05
|
1
| | | | | |
|
≥ 0.05
|
1.91
|
1.40–2.60
|
< 0.001
| | | |
|
CEA
|
|
≤ 5 ng/mL
|
1
| | | | | |
|
> 5 ng/mL
|
1.76
|
1.16–2.68
|
0.008
| | | |
- HR Hazard ratios, CI Confidence interval, BMI Body mass index, PNI Prognostic nutritional index, PI Prognostic index, GPS Glasgow Prognostic Score, mGPS Modified Glasgow Prognostic Score, NLR Neutrophil-lymphocyte ratio, PLR Platelet-lymphocyte ratio, CRP/Alb C-reactive protein/albumin, SII Systemic immune-inflammatory index
