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Table 1 Univariate and multivariate analysis of prognostic factors in patients with gastric cancer

From: Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection

Clinicopathological feature Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Age (years)
 ≤ 60 1    1   
 > 60 1.62 1.16–2.25 0.005 1.63 1.15–2.31 0.007
Gender
 Male 1      
 Female 1.01 0.73–1.40 0.967    
BMI
 ≤ 24 kg/m2 1      
 > 24 kg/m2 0.77 0.52–1.13 0.175    
Tumor location
 Upper third 1      
 Middle third 0.53 0.29–0.98 0.041    
 Lower third 0.47 0.31–0.71 < 0.001    
 Two-thirds or more 0.76 0.27–2.15 0.600    
Gastrectomy
 Distal 1      
 Total 1.57 1.10–2.23 0.013    
 Proximal NA      
Tumor size
 ≤ 5 cm 1      
 > 5 cm 2.60 1.90–3.54 < 0.001    
Histologic type
 Differentiated 1      
 Undifferentiated 1.29 0.95–1.76 0.106    
Perineural invasion
 Absence 1      
 Presence 2.73 2.00–3.72 < 0.001    
Lymphovascular invasion
 Absence 1      
 Presence 2.78 2.02–3.83 < 0.001    
T category
 T1 1    1   
 T2 4.30 1.56–11.83 0.005 3.04 1.08–8.57 0.036
 T3 2.04 0.25–16.92 0.510 1.69 0.20–14.50 0.633
 T4a 15.79 6.97–35.76 < 0.001 8.22 3.26–20.75 < 0.001
 T4b 28.21 9.78–81.36 < 0.001 13.05 3.98–42.82 < 0.001
N category
 N0 1    1   
 N1 3.22 1.76–5.90 < 0.001 1.70 0.88–3.26 0.112
 N2 4.71 2.75–8.05 < 0.001 2.09 1.15–3.81 0.016
 N3a 11.35 6.82–18.89 < 0.001 5.38 3.00–9.65 < 0.001
 N3b 24.19 13.27–44.07 < 0.001 11.01 5.50–22.04 < 0.001
Chemotherapy
 No 1    1   
 Yes 1.58 1.12–2.22 0.009 0.70 0.48–1.01 0.059
Number of lymph nodes retrieved
 ≤ 15 1    1   
 16–29 0.75 0.50–1.13 0.169 0.46 0.30–0.70 < 0.001
 ≥ 30 1.36 0.88–2.11 0.166 0.52 0.32–0.84 0.008
PI
 0 1      
 1 1.54 0.96–2.49 0.075    
PNI
 < 49.5 1      
 ≥ 49.5 0.40 0.27–0.59 < 0.001    
Fibrinogen
 < 397 ng/dl 1      
 ≥ 397 ng/dl 2.06 1.51–2.81 < 0.001    
NLR
 < 2.5 1    1   
 ≥ 2.5 1.69 1.24–2.31 0.001 0.70 0.48–1.01 0.059
PLR
 < 154 1    1   
 ≥ 154 2.21 1.62–3.01 < 0.001 1.70 1.20–2.42 0.003
SII
 < 556 1      
 ≥ 556 1.94 1.43–2.64 < 0.001    
GPS
 0 1      
 1 1.76 1.24–2.49 0.002    
 2 1.89 1.04–3.43 0.037    
mGPS
 0 1      
 1 1.53 0.68–3.46 0.307    
 2 1.66 0.92–3.00 0.091    
CRP/Alb
 < 0.05 1      
 ≥ 0.05 1.91 1.40–2.60 < 0.001    
CEA
 ≤ 5 ng/mL 1      
 > 5 ng/mL 1.76 1.16–2.68 0.008    
  1. HR Hazard ratios, CI Confidence interval, BMI Body mass index, PNI Prognostic nutritional index, PI Prognostic index, GPS Glasgow Prognostic Score, mGPS Modified Glasgow Prognostic Score, NLR Neutrophil-lymphocyte ratio, PLR Platelet-lymphocyte ratio, CRP/Alb C-reactive protein/albumin, SII Systemic immune-inflammatory index
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