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Table 1 Patient characteristics according to vascular invasion

From: Next-generation des-r-carboxy prothrombin for immunohistochemical assessment of vascular invasion by hepatocellular carcinoma

  

Positive vascular invasion group

Negative vascular invasion group

p value

(n = 13)

(n = 43)

Gender

(male)

7 (53.9%)

26 (60.5%)

0.37

(female)

6 (46.1%)

17 (39.5%)

 

Age

(years)

70 (41–82)

73 (43–82)

0.81

HBV infectiona

 

4 (30.8%)

15 (34.9%)

0.78

HCV infectionb

 

8 (61.5%)

26 (60.5%)

0.94

Recurrence of hepatocellular carcinoma

 

5 (38.5%)

13 (30.2)

0.58

Aspartate aminotransferase

(IU/dL)

31 (17–84)

38 (14–139)

0.25

Alanine aminotransferase

(IU/dL)

26 (13–55)

36 (12–157)

0.26

Albumin

(g/dL)

4.1 (3.0–5.0)

4.0 (2.8–4.8)

0.36

Total bilirubin

(mg/dL)

0.72 (0.46–1.46)

0.72 (0.26–2.12)

0.94

Prothrombin activity

(%)

100 (82–100)

100 (68–100)

0.78

Platelets count

(mm4/dL)

15.3 (5.8–33.9)

11.5 (4.2–22.7)

0.08

Conventional DCP

(mAU/mL)

69 (8–3549)

22 (9–475)

0.04

Next-generation DCP

(mAU/mL)

74 (17–574)

30 (16–813)

0.01

Alpha-fetoprotein

(ng/mL)

9.7 (1.6–1208.7)

10.6 (1.6–453.2)

0.58

Pathological fibrosis gradec

   

0.07

 f1

 

4

3

 

 f2

 

4

9

 

 f3

 

1

11

 

 f4

 

4

20

 

Pathological hepatitis gradec

   

0.33

 a1

 

4

13

 

 a2

 

4

15

 

 a3

 

4

15

 

 a4

 

1

0

 

Tumor diameter

(mm)

28 (11–50)

22 (9–38)

0.06

Tumor differentiation

 Well-differentiated

 

0 (0%)

9 (20.9%)

0.02

 Modelately differentiated

 

11 (84.6%)

30 (76.7%)

0.81

 Poorly differentiated

 

2 (15.4%)

3 (7.0%)

0.38

 Others

 

0

1 (2.3%)

0.41

Fibrous capsule infiltration of tumor

 

6 (46.2)

19 (44.2)

0.89

  1. a Hepatitis B virus; b hepatitis C virus; c according to the new Inuyama classification, DCP Des-r-carboxy prothrombin