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Table 1 Patients’ clinicopathological variables

From: Combined prognostic nutritional index ratio and serum amylase level during the early postoperative period predicts pancreatic fistula following pancreaticoduodenectomy

Variables

POPF group (n = 54)

non-POPF group (n = 138)

P value

Age, year, median (range)

69.7 (31–84)

70.9 (17–86)

0.604

Sex, male, (n, %)

42 (77.8%)

79 (57.2%)

0.008

Body mass index, median (range)

23.3 (16.5–29.6)

21.5 (15.1–31.5)

0.001

Histological diagnosis

  

0.001

 pancreatic ductal adenocarcinoma

9 (16.7%)

64 (46.4%)

 

 acinar sell cancer

0 (0%)

1 (0.7%)

 

 bile duct cancer

22 (40.7%)

20 (14.5%)

 

 carcinoma of the papilla of Vater

12 (22.2%)

21 (15.2%)

 

 IPMN

6 (11.1%)

17 (12.3%)

 

 PNET

1 (1.9%)

6 (4.3%)

 

 SPN

1 (1.9%)

1 (0.7%)

 

 Others

3 (5.6%)

8 (5.8%)

 

Preoperative biliary drainage, present, (n, %)

30 (55.6%)

53 (38.4%)

0.031

Pancreatic texture of remnant pancreas, soft, (n, %)

49 (90.7%)

68 (49.3%)

<  0.001

Diameter of main pancreatic duct, median (range), mm

2.6 (1.0–8.9)

4.3 (1.0–12.7)

<  0.001

Operative time, median (range), (min)

545 (403–823)

525 (309–780)

0.271

Intraoperative blood loss, median (range), (ml)

570 (64–4016)

557 (95–2950)

0.240

Method of pancreaticojejunostomy, modified BA, (n, %)

28 (51.9%)

97 (70.3%)

0.016

Preoperative serum albumin level, median (range), (g/dl)

4.0 (1.0–5.2)

4.0 (2.1–4.9)

0.607

Preoperative total lymphocyte count, median (range), (/μl)

1504 (875–3168)

1460 (550–5382)

0.338

Serum amylase level on POD 1, median (range), (IU/l)

432 (136–3953)

246 (12–2324)

<  0.001

Serum amylase level on POD 3, median (range), (IU/l)

102 (28–665)

64 (8–1406)

0.001

Drain amylase level on POD 1, median (range), (IU/l)

8652 (66–985,053)

957.5 (12–65,568)

<  0.001

Drain amylase level on POD 3, median (range), (IU/l)

1313 (450–42,370)

187.5 (4–23,814)

<  0.001

Serum CRP level on POD 1 (range), (mg/dl)

7.83 (4.33–17.76)

7.32 (1.04–20.46)

0.160

Serum CRP level on POD 3 (range), (mg/dl)

21.68 (4.85–37.52)

11.46 (0.88–37.56)

<  0.001

Preoperative PNI, median (range)

48.4 (36.6–59.8)

47.7 (24.6–72.9)

0.439

PNI on POD 1, median (range)

31.3 (22.7–41.6)

31.4 (19.4–46.5)

0.795

PNI on POD 3, median (range)

29.5 (23.5–40.3)

32.4 (22.2–49.1)

0.007

PNIP1-Pre ratio, median (range)

65.3 (49–92)

67.6 (41–108)

0.577

PNIP3-Pre ratio, median (range)

62.4 (46–82)

68.3 (44–111)

0.003

PNIP3-P1 ratio, median (range)

94.6 (65–122)

101.7 (75–140)

<  0.001

  1. PD pancreaticoduodenectomy, POPF postoperative pancreatic fistula, IPMN intraductal papillary mucinous neoplasm, PNET pancreatic neuroendocrine tumor, SPN solid pseudopapillary neoplasm, BA Blumgart anastomosis, POD postoperative day, CRP C-reactive protein, PNI prognostic nutritional index
  2. Continuous variables are expressed as median with range