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Table 1 Reported cases of laryngeal rhabdomyosarcoma in adults

From: Adult laryngeal Embryonal Rhabdomyosarcoma: a case report and literature review

Author/YR Age/sex Primary Location Symptoms or signs Histologic subtype Treatment Status by end of follow up
Mungan S [1], 2016 64/M Glottic Hoarseness for 2 months Pleomorphic Total laryngectomy with left radical neck dissection and radiotherapy (6MV photons in an Elekta Synergy Platform linear accelerator) Alive & disease-free, 24 months
Chiramel GK [6], 2015 70/M Supraglottic Hoarseness for 2 years Pleomorphic Chemotherapy (protocol was not provided) Loss to follow-up
Li Y [7], 2015 22/F Glottic Hoarseness for 1 month Embryonal Right cordectomy and selective neck dissection Alive & disease-free, 60 months
Russell JO [8], 2015 45/M Glottic Hoarseness for 11 months Embryonal Chemoradiation (vincristine, actinomycin, and cyclophosphamide combined with radiation dose of 50.4 Gy) Alive, 34 months
Kukwa W [4], 2011 33/M Supraglottic Longstanding hoarseness Embryonal Hemilaryngectomy and chemotherapy Alive & disease-free, 62 months
Leventhal DD [9], 2010 54/F Glottic Hoarseness for 9 months Alveolar Microsurgery by CO2 laser Alive & disease-free, 12 months
Pittore B [3], 2010 75/M Glottic Dysphonia for 1 year Pleomorphic Partial left laryngectomy Alive & disease-free, 9 months
Papacharalampous GX [10], 2009 83/F Subglottic Progressive dyspnoea for 3 months Pleomorphic Emergency tracheostomy and endoscopic tumour excision dead (disease-free), 16 months
Schrock A [2], 2007 60/M Glottic Hoarseness for 1 months Pleomorphic Total laryngectomy with a bilateral selective neck dissection Alive & disease-free, 20 months
  66/M Glottic Dyspnea for 6 weeks and hoarseness for 2 weeks Pleomorphic Microsurgery by CO2 laser Alive & disease-free, 20 months
Dikbas O [11], 2005 28/M Glottic Hoarseness for 15 days Embryonal Tracheostomy with biopcy and chemoradiation (cisplatin, vincristine, doxorubicin, and
Cyclophosphamide; protocol of radiotherapy was not provided)
Alive & disease-free, 22 months
Libera DD [12], 1999 66/M Supraglottic Hoarseness and sense of throat fullness Embryonal (botryoid) Partial laryngectomy Alive & disease-free, 10 years
Ruske DR [13], 1998 66/F Supraglottic Hoarseness and dyspnoea for 2 months Pleomorphic Total laryngectomy and radiotherapy (7040 cGys) Alive & disease-free, 30 months
Akyol MU [14], 1998 63/M Supraglottic Hoarseness and increasing dyspnea for 3 months Pleomorphic Total laryngectomy with right modified radical neck dissection and radiotherapy (6000 cGy to the tumor bed and 5000 cGy to the neck was given with cobalt 60 at a dose of 200 cGy/day) Died of extensive lung metastases, 8 months
Da Mosto MC [15], 1996 69/M Glottic Progrossive dysphonia for 7 months Pleomorphic Total laryngectomy and radiotherapy (6000 cGy over 6 weeks in 30 fractions) Alive & disease-free, 24 months
Balázs M [16], 1989 40/M Supraglottic Hoarseness several years Embryoid (Botryoid) Microsurgery Alive & disease-free, 36 months
Haerr RW [17], 1987 62/M Supraglottic Dysphagia several days Alveolar Total laryngectomy with left radical neck dissection and radiotherapy ((4000 cGy in 22 fractions) Died of extensive distant metastases, 5 months
Srinivasan U [18], 1979 55/M Supraglottic Hoarseness, dysphagia and a burning sensation in the throat for two months Pleomorphic Laryngectomy planned Died prior to surgery of acute laryngeal obstruction
Winter LK [19], 1978 72/M Glottic Hoarseness 2 months Pleomorphic Radical removal Alive & disease-free, 9 months
Frugoni (Verona) [20] P, 1976 33/M Supraglottic Hoarseness 3 months Pleomorphic Partial laryngectomy and radiotherapy (protocol was not provided) Alive & disease-free, 6 years
Hall-Jones J [21], 1975 54/M Supraglottic dramatically with a large tumour mass obstructing his laryngeal inlet Embryonal Total laryngectomy Alive & disease-free, 15 months
Rodriguez LA [22], 1970 57/M Glottic Acute respiratory distress Pleomorphic Total laryngectomy No follow-up reported
  1. Abbreviations: YR Year, F Female, M Male, Gy Gray, cGy Centigray