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Table 3 PH assumption for the extended Cox and frailty models

From: Survival analysis in gastric cancer: a multi-center study among Iranian patients

  PH assumption Frailty
HR P P (rho) HR P
Age (year)
  < 60 Ref -  
  > 60 1.25 0.08 0.0156 1.32 0.03
Sex
 Male Ref -  
 Female 0.91 0.48 0.89 0.38
Marital status
 Unmarried Ref -  
 Married 1.88 0.041 1.74 0.07
Education
 Illiterate Ref -  
 Less than diploma 0.92 0.58 0.97 0.88
 University 0.91 0.6 0.91 0.59
Family history
 Yes Ref -  
 No 0.84 0.17 0.87 0.3
BMI
  < 18 2.7 < 0.001 0.0164 2.6 0.001
 18–25 1.17 0.54 1.04 0.81
  > 25 Ref -  
Smoking status
 No Ref -  
 Yes 1.08 0.52 1.11 0.41
Tumor type
 Other Ref -  
 Adenocarcinoma 0.97 0.91 0.94 0.81
 Lymphoma 0.89 0.72 0.81 0.49
Lymph node
 N1 Ref -  
 N2 1.25 0.08 1.21 0.14
 N3 0.83 0.43 0.83 0.43
Metastasis
 No Ref -  
 Yes 0.95 0.71 0.98 0.86
Treatment < 0.001  
 Chemotherapy+ radiotherapy Ref -  
 Surgery+ chemotherapy 0.69 0.001 0.81 0.021
 Surgery 0.91 0.05 0.9 0.056
Tumor size
 T1 Ref -  
 T2 2.37 0.01 0.0158 2.27 0.013
 T3 3.04 0.002 2.53 0.008
Grade
 Undifferentiated Ref -  
 Well 0.51 0.12 0.43 0.047
 Moderate 0.30 0.002 0.26 0.001
 Poorly 0.56 0.125 0.54 0.099
Variable Coefficient P
   Variance of Frailty 1.67 0.04