Table 3 PH assumption for the extended Cox and frailty models
From: Survival analysis in gastric cancer: a multi-center study among Iranian patients
PH assumption | Frailty | |
|---|---|---|
HR P | P (rho) HR P | |
Age (year) | ||
< 60 | Ref - | |
> 60 | 1.25 0.08 | 0.0156 1.32 0.03 |
Sex | ||
Male | Ref - | |
Female | 0.91 0.48 | 0.89 0.38 |
Marital status | ||
Unmarried | Ref - | |
Married | 1.88 0.041 | 1.74 0.07 |
Education | ||
Illiterate | Ref - | |
Less than diploma | 0.92 0.58 | 0.97 0.88 |
University | 0.91 0.6 | 0.91 0.59 |
Family history | ||
Yes | Ref - | |
No | 0.84 0.17 | 0.87 0.3 |
BMI | ||
< 18 | 2.7 < 0.001 | 0.0164 2.6 0.001 |
18–25 | 1.17 0.54 | 1.04 0.81 |
> 25 | Ref - | |
Smoking status | ||
No | Ref - | |
Yes | 1.08 0.52 | 1.11 0.41 |
Tumor type | ||
Other | Ref - | |
Adenocarcinoma | 0.97 0.91 | 0.94 0.81 |
Lymphoma | 0.89 0.72 | 0.81 0.49 |
Lymph node | ||
N1 | Ref - | |
N2 | 1.25 0.08 | 1.21 0.14 |
N3 | 0.83 0.43 | 0.83 0.43 |
Metastasis | ||
No | Ref - | |
Yes | 0.95 0.71 | 0.98 0.86 |
Treatment | < 0.001 | |
Chemotherapy+ radiotherapy | Ref - | |
Surgery+ chemotherapy | 0.69 0.001 | 0.81 0.021 |
Surgery | 0.91 0.05 | 0.9 0.056 |
Tumor size | ||
T1 | Ref - | |
T2 | 2.37 0.01 | 0.0158 2.27 0.013 |
T3 | 3.04 0.002 | 2.53 0.008 |
Grade | ||
Undifferentiated | Ref - | |
Well | 0.51 0.12 | 0.43 0.047 |
Moderate | 0.30 0.002 | 0.26 0.001 |
Poorly | 0.56 0.125 | 0.54 0.099 |
Variable Coefficient P | ||
Variance of Frailty 1.67 0.04 | ||