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Table 1 Analysis of potential factors as predictors of postoperative HA

From: Hypoalbuminemia after pancreaticoduodenectomy does not predict or affect short-term postoperative prognosis

Factor

HA(n = 61)

non-HA(n = 102)

Univariate

Multivariate

OR

95% CI

P value

OR

95% CI

P value

Patient characteristics

 Gender

  Male

29

62

1

     

  Female

32

40

0.604

0.317–1.149

0.124

   

 Age (years)a

59.6 ± 8.5

56.6 ± 9.7

1.036

1.000–1.074

0.051

   

 Weight loss > 5 kg

  Yes

16

31

1

     

  No

45

71

0.621

0.284–1.357

0.232

   

BMI(kg/m2)a

21.6 ± 3.1

21.6 ± 3.3

1.000

0.884–1.131

0.996

   

 Diabetes mellitus

  No

58

97

1

     

  Yes

3

5

1.021

0.235–4.433

0.978

   

 Acute pancreatitis

  No

59

98

1

     

  Yes

2

4

0.845

0.150–4.757

0.848

   

 Chronic pancreatitis

  No

42

57

1

     

  Yes

19

45

1.021

0.235–4.433

0.978

   

 Preoperative biliary drainage

  No

58

94

1

     

  Yes

3

8

0.618

0.158–2.427

0.491

   

 Preoperative ALB usage

  No

58

97

1

     

  Yes

3

5

0.276

0.046–1.638

0.157

   

 Preoperative ALB usage a(g)

14.7 ± 4.2

34.5 ± 9.4

0.999

0.975–1.023

0.910

   

 WBC(× 109/L)a

6.6 ± 2.3

6.3 ± 2.1

1.074

0.926–1.247

0.346

   

 NEUT(×109/L)a

4.6 ± 2.0

4.3 ± 1.9

1.087

0.923–1.280

0.319

   

 LYMP(×109/L)a

1.2 ± 0.5

1.4 ± 0.6

0.631

0.337–1.182

0.151

   

 CRP (mg/L) a

16.1 ± 5.4

19.7 ± 7.6

1.011

0.968–1.056

0.617

   

 RBC (× 1012/L)a

3.8 ± 0.5

3.9 ± 0.6

0.720

0.402–1.290

0.270

   

 Hb(g/L)a

116.3 ± 17.6

119.8 ± 19.4

0.990

0.973–1.007

0.263

   

 HCT(%)a

33.6 ± 4.9

36.7 ± 4.6

0.863

0.719–1.035

0.112

   

 PLT (×109/L)a

206.7 ± 90.4

224.6 ± 94.6

0.998

0.994–1.002

0.247

   

 PT(s)a

11.5 ± 1.7

11.3 ± 1.6

1.089

0.891–1.330

0.406

   

 APTT(s)a

28.2 ± 4.7

27.4 ± 4.9

1.032

0.964–1.104

0.371

   

 TT(s)a

19.8 ± 2.9

19.4 ± 2.5

1.062

0.937–1.203

0.346

   

 INRa

0.9 ± 0.1

0.9 ± 0.2

1.763

0.180–7.228

0.626

   

 ALT (U/L) a

112.3 ± 95.2

162.3 ± 78.8

0.997

0.995–1.000

0.057

   

 AST (U/L) a

96.0 ± 65.1

115.6 ± 94.7

0.997

0.993–1.001

0.165

   

 ALP (U/L) a

509.3 ± 390.1

498.4 ± 374.0

1.000

0.999–1.001

0.861

   

 TBIL ≥171.1 (μmol/L)

  No

34

76

1

     

  Yes

27

26

2.214

1.117–4.390

0.023

0.997

0.267–3.720

0.997

 TP (g/L) a

59.4 ± 2.8

61.7 ± 6.0

0.905

0.755–1.084

0.279

   

 Preoperative ALB ≥35.0 (g/L)

  No

25

26

1

     

  Yes

36

76

0.480

0.241–0.955

0.037

0.447

0.210–0.952

0.037

 GLB (g/L) a

25.7 ± 3.5

24.9 ± 3.7

1.062

0.853–1.323

0.588

   

 PA (mg/L) a

201.8 ± 95.9

187.2 ± 71.7

1.002

0.997–1.007

0.366

   

 AMY (U/L) a

85.0 ± 59.2

145.6 ± 106.3

0.996

0.988–1.004

0.347

   

 CA19–9 (U/mL)a

648.5 ± 133.7

622.8 ± 147.2

1.000

1.000–1.000

0.941

   

 Site of Lesion

  Distal common bile duct

18

17(16.7)

1

 

0.262

   

  Duodenal papilla

17(27.9)

32(31.4)

0.472

0.193–1.155

0.100

   

  Pancreatic head

21(34.4)

41(40.2)

0.561

0.234–1.342

0.194

   

  Ampullary

5(8.2)

12(11.8)

0.747

0.557–1.003

0.052

   

Intra-Operative factors

 Operation time (h) a

7.6 ± 1.5

7.8 ± 1.7

0.923

0.754–1.129

0.435

   

 Estimated Blood loss(ml) a

591.5 ± 451.2

497.4 ± 311.1

1.001

1.000–1.002

0.128

   

 pRBC transfusion (U) a

1.7 ± 0.6

1.5 ± 0.5

1.081

0.881–1.325

0.455

   

 Plasma transfusion(ml)

237.5 ± 80.3

132.8 ± 50.9

1.002

1.000–1.004

0.009

1.002

1.000–1.003

0.057

 Total liquid volume(ml)

5829.2 ± 1431.7

6171.3 ± 1544.2

1.000

1.000–1.000

0.275

   

 Ratio of crystal fluid/colloid fluid

1.8 ± 0.5

2.3 ± 0.6

0.219

0.046–1.040

0.056

   

 Pancreatic gland texture

  Soft

36

58

1

     

  Hard

25

44

0.603

0.322–1.129

0.114

   

 Pancreatic duct diameter > 0.3 cm

  No

27

25

1

  

1

  

  Yes

34

77

0.425

0.215–0.839

0.014

0.819

0.369–1.815

0.622

 PJ-R Type

        

  IPJ (external stenting)

49

81

1

 

0.219

   

  DMPJ (external stenting)

0

2

   

  DMPJ (internal stenting)

4

14

1.189

0.449–3.152

0.728

   

  IPJ (no stenting)

5

4

5.833

0.953–7.717

0.056

   

  IPJ (internal stenting)

3

1

1.460

0.914–2.330

0.113

   

 Combined portal vein resection

  No

60

100

1

     

  Yes

1

2

1.180

0.105–3.296

0.893

   

 Resectional margin status

  R0b

53

91

1

 

0.697

   

  R1

5

5

1.692

0.468–6.124

0.423

   

  R2

3

6

1.046

0.559–1.956

0.889

   

Pathological characteristics and postoperative complications

 Pathology

  Adenocarcinoma

59(96.7)

85(83.3)

1

 

0.949

   

  Mucinous adenocarcinoma

0(0)

5(4.9)

   

  Inflammation mass

2

10

0.754

0.565–1.005

0.054

   

  Sarcoma

0

1

   

  Retention cyst

0

1

   

 Tumor Differentiation

  Inflammation

2

11

1

 

0.570

   

  High

26

45

0.900

0.356–2.274

0.824

   

  Moderate

23

27

1.033

0.592–3.974

0.379

   

  Poor

10

19

1.167

0.758–1.797

0.484

   

 Clavien-Dindo grade

  0

28

61

1

 

0.262

1

 

0.173

  I

11

25

0.472

0.193–1.155

0.100

0.620

0.105–3.656

0.597

  II

12

6

0.561

0.234–1.342

0.194

1.127

0.179—7.085

0.899

  IIIa

2

5

3.765

0.897–9.296

0.067

1.582

0.316–7.927

0.577

  IIIb

2

4

3.351

1.641–6.845

0.001

4.317

1.479–12.602

0.007

  IVa

2

0

  IVb

0

0

  V

4

1

1.654

1.186–2.306

0.003

1.605

1.097–2.349

0.015

  1. Abbreviations: OR odds ratio, BMI body mass index, TBIL total bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, TP total protein, GLB globulin, ALB albumin, PA prealbumin, AMY amylase, CRP C-reactive protein, RBC red blood cell count, WBC white blood cell count, NEUT neutrophil count, LYMP lymphocyte count, Hb hemoglobin, PLT platelet count, HCT hematocrit, PT prothrombin time, APTT activated partial thromboplastin time, TT thrombin time, INR international normalized ratio, CA19–9 carbohydrate antigen 19–9, pRBC packed red blood cell, PJ-R pancreaticojejunostomy reconstruction, DMPJ duct-to-mucosa end-to-side pancreaticojejunostomy, IPJ invagination pancreaticojejunostomy
  2. a expressed as Mean ± SD;
  3. bThe resectional margin status in non-malignant disease was classified and analyzed as R0