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Table 3 Radiological and pathological response to neoadjuvant chemotherapy and description of chemotherapy-related liver complications

From: Tumor response and outcome after reverse treatment for patients with synchronous colorectal liver metastasis: a cohort study

  

N = 44

 

Radiological response (RECIST)

CR

0

0%

PR

27

61%

SD

12

27%

PD

1

2%

n.a.

4

9%

Pathological response a

TRG 1

1

2%

TRG 2

12

27%

TRG 3

10

23%

TRG 4

17

39%

TRG 5

4

9%

Chemotherapy-related liver injury

Steatosis

26

59%

 Minimal

3

 

 Grade 1

17

 

 Grade 2

2

 

 Grade 3

4

 

SOS

17

39%

 Grade 1

11

 

 Grade 2

6

 

Fibrosis

16

36%

 F1

14

 

 F2

2

 

Steatohepatitis

15

11%

  1. CR Complete response; PR partial response; SD Stable disease; PD Progressive disease; n.a N
  2. ot assessed; TRG Tumor regression grade; SOS Sinusoidal obstruction syndrome.
  3. a Pathological response according to Rubbia-Brandt et al.13 with report of the worst TRG score in case of multiple metastases with discordant response between lesions