Intrahepatic cholangiocarcinoma – influence of resection margin and tumor distance to the liver capsule on survival

Table 4 Univariate and multivariate analyses

		Kaplan Meier Model		Multivariate Cox regression model
		OS	RFS	OS			RFS
		OS	RFS	HR	95% CI	p-value	HR	95% CI	p-value
Resection margin	> 0.5 cm / 0.49–0.1 cm / R1	0.230	0.111
	> 0.5 cm / < 0.49 cm	0.087	0.052	0.754	0.428–1.326	0.326	0.557	0.331–0.936	0.027
	≤0.1 cm / > 0.1 cm	0.291	0.458
Tumor distance to liver capsule	dist./cl. + infil./perf./pd. Infil.	0.033	0.136	1.271	1.058–1.525	0.010
Age	< 65 / > 65	0.073	0.175	1.536	1.026–2.300	0.037
Gender	Woman / Man	0.283	0.472
Extended resection	yes / no	0.009	0.024	0.848	0.514–1.400	0.519	0.884	0.553–1.413	0.606
Major resection	yes / no	0.045	0.008	0.573	0.351–0.936	0.026	0.735	0.464–1.165	0.191
Tumor size	≤5 cm / > 5 cm	0.108	0.008
Tumor size	≤ 10 cm / > 10 cm	0.014	0.002	1.609	1.007–2.570	0.047	1.973	1.272–3.061	0.002
Multifocality	yes / no	0.262	0.014				1.593	1.069–2.374	0.022
T-stage	T1 + T2 / T3 + T4	0.102	0.347
N-stage	N0 / N+ / NX	0.016	0.085	1.258	1.027–1.541	0.026	1.147	0.931–1.412	0.197
V-stage	V0 / V1 + V2	0.149	0.818
L-stage	L0 / L1	0.369	0.673
Pn-stage	Pn0 / Pn1	0.027	0.091	1.401	0.882–2.227	0.154	1.157	0.748–1.789	0.512
M-stage	M0 / M1	0.125	0.002				2.984	1.347–6.612	0.007
R-stage	R0 / R1	0.655	0.254
Grading	G1 + G2 / G3 + G4	0.347	0.535

Perioperative deaths were excluded for statistical analyses; significant parameters are bold; parameters with p < 0.1 were included in multivariate analyses (underlined); OS overall survival, RFS recurrence-free survival, HR hazard ratio, 95% CI = 95% confidence interval, dist./cl. + infil./perf./pd. Infil. = distant / close+infiltration / perforation / periductal infiltration

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