Fig. 4

Plasma concentrations of interleukin-6 (IL-6, panel a), interleukin-8 (IL-8, panel b), interleukin-10 (IL-10, panel c) and tumor necrosis factor alpha (TNF-α, panel d) in anesthetized pigs subjected to Zone I resuscitative endovascular balloon occlusion of the aorta (I) for 15 min (REBOA15), 30 min (REBOA30), 60 min (REBOA60) and control conditions (no occlusion) and reperfusion for 3 h (n = 6 per group). Data are means and 95% confidence intervals. a Statistically significant difference compared to controls. b Statistically significant difference compared to REBOA 15 min. c Statistically significant difference compared to REBOA 30 min. d Statistically significant difference compared to REBOA 60 min