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Table 3 Association between perioperative recipient and donor-graft parameters and early post-transplant bacteremia in patients undergoing living donor liver transplantation

From: Risk stratification for early bacteremia after living donor liver transplantation: a retrospective observational cohort study

 

Univariate analysis

Multivariate analysis

β

Odds ratio

95% CI

p

β

Odds ratio

95% CI

p

Preoperative recipient parameters

Age (years)

−0.002

0.998

0.967–1.029

0.893

    

Sex (female)

−0.087

0.916

0.500–1.680

0.777

    

Body mass index (kg·m-2)

−0.057

0.945

0.876–1.019

0.142

    

Psoas muscle index (mm2·m-2)

−0.004

0.996

0.993–0.999

0.017

−0.004

0.996

0.993–0.999

0.019

Comorbidity

 Diabetes mellitus

−0.303

0.738

0.380–1.436

0.371

    

 Hypertension

−0.035

0.965

0.484–1.927

0.921

    

MELD score (point)

0.042

1.042

1.019–1.066

<0.001

    

CRRT

0.923

2.516

1.323–4.784

0.005

0.710

2.034

1.004–4.125

0.049

Hepatocellular carcinoma

−0.473

0.623

0.350–1.108

0.107

    

 Beyond Milan criteria

−0.345

0.708

0.079–6.356

0.758

    

Hepatic decompensation

 Encephalopathy

−0.061

0.940

0.359–2.463

0.900

    

 Varix

−0.196

0.822

0.422–1.601

0.565

    

 Ascites

0.478

1.613

0.929–2.803

0.090

    

Cardiac function

 Ejection fraction (%)

0.036

1.036

0.973–1.104

0.267

    

 Diastolic dysfunction

0.048

1.050

0.605–1.820

0.863

    

Laboratory variables

 Hemoglobin (g·dL-1)

−0.063

0.939

0.827–1.066

0.331

    

 WBC count (×109·L-1)

0.009

1.009

0.965–1.054

0.701

    

 C-reactive protein to albumin ratio (%)

0.439

1.551

1.198–2.007

0.001

    

 Neutrophil to lymphocyte ratio (%)

0.052

1.053

1.020–1.087

0.002

0.032

1.032

1.000–1.066

0.048

 Platelet to lymphocyte ratio

0.002

1.002

1.000–1.004

0.064

    

 Sodium (mEq·L-1)

−0.041

0.960

0.916–1.006

0.089

    

 Potassium (mEq·L-1)

0.009

1.009

0.645–1.579

0.968

    

 Glucose (mg·dL-1)

−0.001

0.999

0.994–1.004

0.796

    

Intraoperative recipient parameters

Surgical duration (min)

0.000

1.000

0.998–1.003

0.775

    

Post-reperfusion syndrome

0.568

1.765

0.981–3.174

0.058

    

Mean vital sign values

 MBP (mmHg)

−0.008

0.992

0.963–1.022

0.601

    

 HR (beats·min-1)

0.012

1.012

0.993–1.032

0.210

    

 CVP (mmHg)

0.092

1.097

1.011–1.190

0.026

    

Mean lactate (mmol·L-1)

0.036

1.036

0.971–1.107

0.286

    

Blood product transfusion (unit)

 Packed red blood cells

0.038

1.039

1.014–1.064

0.002

    

 Fresh frozen plasma

0.031

1.032

1.002–1.063

0.039

    

 Single donor platelets

0.015

1.015

0.916–1.126

0.774

    

Hourly fluid infusion (mL·kg-1·h-1)

0.016

1.016

0.997–1.035

0.094

    

Hourly urine output (mL·kg-1·h-1)

−0.250

0.779

0.589–1.029

0.079

    

Donor-graft parameters

Age (years)

0.011

1.011

0.988–1.036

0.354

    

Sex (female)

0.039

1.040

0.583–1.856

0.894

    

Body mass index (kg.m-2)

−0.003

0.997

0.911–1.091

0.945

    

GRWR (%)

0.304

1.355

0.672–2.734

0.396

    

ABO-incompatible graft

0.359

1.432

0.615 – 3.333

0.405

    

Graft ischemic time (min)

0.001

1.001

0.998–1.004

0.653

    

Fatty change (%)

0.025

1.025

0.993–1.059

0.125

    

Early postoperative parameters

Early allograft dysfunction

1.420

4.136

2.255–7.586

<0.001

1.199

3.315

1.721–6.388

<0.001

Acute kidney injury

0.421

1.523

0.866–2.680

0.144

    

Biliary stricture or leakage

0.411

1.508

0.765–2.974

0.236

    

Mechanical ventilation duration (min)

0.000

1.000

1.000 – 1.000

0.780

    

Acute graft rejection

-0.594

0.552

0.244 – 1.252

0.155

    
  1. Abbreviations: CRRT Continuous renal replacement therapy, MELD Model for end-stage liver disease, WBC White blood cell, GRWR Graft-recipient-weight-ratio, MBP Mean blood pressure, HR Heart rate, CVP Central venous pressure, CI Confidence interval