The predictors and patterns of the early recurrence of pancreatic ductal adenocarcinoma after pancreatectomy: the influence of pre- and post- operative adjuvant therapy

Table 1 Univariate and multivariate analyses of the clinical factors affecting the recurrence of PDAC within 6 months after surgery

		Group E (n = 34)^b	Group NE (n = 81)^c	P-value	OR	95% CI	P-value^※
Preoperative variables
Age^a	≧ 68	23 (68%)	46 (57%)	0.278
Sex	Male	19 (56%)	43 (53%)	0.784
BMI^a	≦ 21.5	13 (59%)	27 (44%)	0.233
Tumor location	head	23 (68%)	54 (67%)	0.919
Resectability	BR	10 (29%)	19 (23%)	0.502
CRP^a	≧ 0.18	17 (61%)	32 (43%)	0.103
CA19–9^a	≧ 173	21 (62%)	30 (39%)	0.026
NLR^a	≧4.65	8 (40%)	10 (16%)	0.020
Lymphocyte count^a	≦1648	25 (96%)	58 (79%)	0.038
mGPS	1 or 2	7 (21%)	13 (17%)	0.382
SUV in FDG-PET^a	≧ 4.73	18 (82%)	37 (58%)	0.043
Preoperative CRT	No	23 (68%)	41 (51%)	0.093
Intraoperative variables
Operation time^a	≧ 609	11 (44%)	39 (59%)	0.197
Blood loss^a	≧ 1767	5 (20%)	20 (30%)	0.326
Transfusion	Yes	5 (25%)	15 (23%)	0.860
Portal vein resection	Yes	11 (33%)	26 (35%)	0.893
Postoperative variables
Morbidity	≧CD3	5 (22%)	13 (22%)	0.948
Postoperative CA19–9 normalization	No	17 (81%)	9 (20%)	< 0.001	23.10	4.21–126.86	< 0.001
Postoperative ACT	No	18 (53%)	11 (14%)	< 0.001	10.41	2.73–39.64	0.001
Pathological variables
Tumor size^a	≧ 3.0	22 (65%)	32 (42%)	0.028
Histological grade	G2–4	14 (56%)	36 (50%)	0.564
PALN metastasis	Positive	4 (16%)	1 (2%)	0.009
LN metastases	Positive	20 (59%)	40 (49%)	0.355
CY	Positive	2 (9%)	3 (5%)	0.502
ly	Positive	28 (82%)	57 (70%)	0.182
v	Positive	32 (94%)	73 (90%)	0.488
S	Positive	25 (74%)	38 (47%)	0.009	4.942	1.47–16.62	0.010
RP	Positive	26 (76%)	54 (67%)	0.297
A	Positive	4 (11%)	4 (5%)	0.203
PV	Positive	10 (29%)	21 (27%)	0.757
PL	Positive	21 (62%)	32 (40%)	0.029
Resection status	R1	6 (18%)	5 (6%)	0.056

※; logistic regression analysis
^aThe cutoff values of age, BMI, CRP, Alb, Hb, CA19–9, NLR, lymphocyte count, SUV on FDG-PET, operation time, blood loss, and tumor size were set by drawing a receiver operating characteristic curve
^bRecurrence within 6 months after surgery
^cRecurrence at more than 6 months after surgery

ISSN: 1471-2482