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Table 1 Clinicopathologic characteristics of included studies

From: Surgical treatment to multiple primary lung cancer patients: a systematic review and meta-analysis

Study (Year)PeriodCountryCriteriaTypeCasesMale (%)Female (%)Mean Age (years)SmokerInterval (months)NOS Scale
Van Rens (2000) [11]1970–1997NetherlandsM-MSYN8576 (89.4%)9 (10.6%)65.8NANA6
Doddoli (2001) [12]1985–1999FranceM-MMET3835 (92%)3 (8%)63 ± 83760 ± 516
Trousse (2007) [13]1985–2006FrancedefinedSYN12598 (78.4%)27 (21.6%)61.5 ± 9.9111NA7
De Leyn (2008) [14]1990–2007BelgiumdefinedSYN3629 (80.6%)7 (19.4%)64.5NANA7
Riquet (2008) [15]1993–2005FranceM-MMixed234
SYN – 118
MET – 116
194 (82.9%)40 (17.1%)63.7 ± 9.1NANA6
Lee (2009) [16]1995–2008USAdefinedMET5823 (39.7%)35 (60.3%)67NA426
Voltolini (2010) [17]1990–2007ItalydefinedSYN4340 (93.0%)3 (7.0%)66.7 ± 6.940NA7
Hamaji (2013) [18]2000–2009USAdefinedMET16188 (54.7%)73 (45.3%)7013842.77
Ishikawa (2014) [19]1995–2009JapanModified M-MSYN9336 (38.7%)57 (61.3%)6833NA6
Xiao (2017) [20]2004–2015ChinaM-MSYN5236 (69.2%)16 (30.8%)60.3 ± 8.6138NA7
  1. Notes: M-M Martini-Melamed criteria, SYN Synchronous, MET Metachronous, NOS Newcastle-Ottawa Scaling system