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Table 3 Univariate and multivariate analyses

From: Resection of intrahepatic cholangiocarcinoma in elderly patients – is it reasonable?

  Kaplan Meier Model Multivariate Cox regression model
OS RFS OS RFS
HR 95% CI p-value HR 95% CI p-value
Age > 70 / < 70 0.072 0.047 1.440 0.929–2.232 0.103 1.826 1.179–2.826 0.007
Age > 70 / 50–70 / < 50 0.094 0.034   1   2
Tumor size ≤5 cm / > 5 cm 0.091 0.009*       
  ≤ 10 cm / > 10 cm 0.013 0.002 1.812 1.100–2.985 0.020 2.055 1.294–3.262 0.002
Multifocality yes / no 0.262 0.014     1.701 1.101–2.629 0.017
T-stage T1 + T2 / T3 + T4 0.102 0.347       
N-stage N0 / N1 0.003 0.026 2.121 1.336–3.367 0.001 1.877 1.211–2.908 0.005
V-stage V0 / V1 + V2 0.149 0.818       
L-stage L0 / L1 0.369 0.673       
Pn-stage Pn0 / Pn1 0.027 0.091 1.432 0.889–2.308 0.140    
R-stage R0 / R1 0.655 0.254       
Grading G1 + G2 / G3 + G4 0.248 0.736       
  1. Perioperative deaths were excluded for statistical analyses; significant parameters are bold; 70 years cut-off groups were included in multivariate analyses for OS even if not significant (underlined); ‡ if this age groups were included instead in multivariate analysis, age was eliminated within the first step with a p-value of 0.501 for ‡1 (OS) and 0.103 for ‡2 (RFS); * Only one significant tumor size cut-off was included in multivariate analyses
  2. OS overall survival, RFS recurrence-free survival, HR hazard ratio, 95% CI 95% confidence interval