Resection of intrahepatic cholangiocarcinoma in elderly patients – is it reasonable?

BMC Surgery

Table 3 Univariate and multivariate analyses

		Kaplan Meier Model		Multivariate Cox regression model
		OS	RFS	OS			RFS
		OS	RFS	HR	95% CI	p-value	HR	95% CI	p-value
Age	> 70 / < 70	0.072	0.047	1.440	0.929–2.232	0.103	1.826	1.179–2.826	0.007
Age	> 70 / 50–70 / < 50	0.094	0.034			‡¹			‡²
Tumor size	≤5 cm / > 5 cm	0.091	0.009*
	≤ 10 cm / > 10 cm	0.013	0.002	1.812	1.100–2.985	0.020	2.055	1.294–3.262	0.002
Multifocality	yes / no	0.262	0.014				1.701	1.101–2.629	0.017
T-stage	T1 + T2 / T3 + T4	0.102	0.347
N-stage	N0 / N1	0.003	0.026	2.121	1.336–3.367	0.001	1.877	1.211–2.908	0.005
V-stage	V0 / V1 + V2	0.149	0.818
L-stage	L0 / L1	0.369	0.673
Pn-stage	Pn0 / Pn1	0.027	0.091	1.432	0.889–2.308	0.140
R-stage	R0 / R1	0.655	0.254
Grading	G1 + G2 / G3 + G4	0.248	0.736

Perioperative deaths were excluded for statistical analyses; significant parameters are bold; 70 years cut-off groups were included in multivariate analyses for OS even if not significant (underlined); ‡ if this age groups were included instead in multivariate analysis, age was eliminated within the first step with a p-value of 0.501 for ‡¹ (OS) and 0.103 for ‡² (RFS); * Only one significant tumor size cut-off was included in multivariate analyses
OS overall survival, RFS recurrence-free survival, HR hazard ratio, 95% CI 95% confidence interval

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