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Table 3 Univariate and multivariate analysis for overall survival and disease-free survival in matched cohorts

From: Laparoscopic vs open colorectal cancer surgery in elderly patients: short- and long-term outcomes and predictors for overall and disease-free survival

Variables

Overall survival

Disease-free survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

Gender: male/female

1.11 (0.60–2.08)

0.739

  

0.72 (0.42–1.23)

0.225

  

Operative type: open/lap.*

1.30 (0.76–2.15)

0.224

  

1.41 (0.80–2.47)

0.230

  

CEA > 5

1.53 (1.11–3.58)

0.008

2.32 (1.26–4.98)

0.022

2.35 (1.85–4.39)

< 0.001

1.77 (1.29–4.15)

0.038

ASA: I-II/III-IV

0.93 (0.73–1.94)

0.811

  

1.25 (0.64–2.13)

0.410

  

Comorbidity

1.32 (0.78–2.33)

0.222

  

1.06 (0.53–1.51)

0.639

  

Tumor size ≥5 cm

1.49 (0.97–2.95)

0.156

  

1.14 (0.63–1.97)

0.443

  

N stage

 N0

Reference

Reference

Reference

Reference

 N1

3.60 (1.56–8.30)

0.003

0.36 (0.05–2.77)

0.324

3.93 (1.94–7.96)

< 0.001

0.45 (0.06–3.46)

0.444

 N2

14.37 (6.11–33.82)

< 0.001

1.03 (0.16–1.59)

0.854

12.25 (5.91–25.43)

< 0.001

1.46 (0.20–2.30)

0.714

TNM stage: I-II/III-IV

6.43 (2.93–14.10)

< 0.001

9.82 (3.15–83.55)

0.002

6.26 (3.22–12.18)

< 0.001

9.67 (3.18–79.30)

0.012

Differentiation

0.61 (0.31–1.21)

0.157

      

 Poor

Reference

  

Reference

Reference

 Median

0.63 (0.32–1.25)

0.189

  

0.80 (0.52–1.47)

0.286

  

 High

0.72 (0.40–1.53)

0.279

  

0.75 (0.45–1.33)

0.248

  

Perineural invasion

4.24 (2.21–8.14)

< 0.001

1.57 (1.15–3.21)

0.041

2.12 (1.42–4.25)

0.002

2.09 (1.59–5.32)

0.020

Vascular invasion

2.72 (1.44–5.14)

0.002

1.23 (0.61–2.47)

0.075

1.78 (1.02–3.09)

0.041

1.63 (0.88–2.95)

0.133

Retrieved lymph node

0.85 (0.71–1.72)

0.533

  

0.79 (0.51–1.43)

0.273

  

Postoperative complication

0.96 (0.84–1.98)

0.857

  

1.32 (0.70–2.41)

0.396

  
  1. *lap laparoscopic