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Table 3 Univariate and multivariate analysis for overall survival and disease-free survival in matched cohorts

From: Laparoscopic vs open colorectal cancer surgery in elderly patients: short- and long-term outcomes and predictors for overall and disease-free survival

Variables Overall survival Disease-free survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR (95%CI) P HR (95%CI) P HR (95%CI) P HR (95%CI) P
Gender: male/female 1.11 (0.60–2.08) 0.739    0.72 (0.42–1.23) 0.225   
Operative type: open/lap.* 1.30 (0.76–2.15) 0.224    1.41 (0.80–2.47) 0.230   
CEA > 5 1.53 (1.11–3.58) 0.008 2.32 (1.26–4.98) 0.022 2.35 (1.85–4.39) < 0.001 1.77 (1.29–4.15) 0.038
ASA: I-II/III-IV 0.93 (0.73–1.94) 0.811    1.25 (0.64–2.13) 0.410   
Comorbidity 1.32 (0.78–2.33) 0.222    1.06 (0.53–1.51) 0.639   
Tumor size ≥5 cm 1.49 (0.97–2.95) 0.156    1.14 (0.63–1.97) 0.443   
N stage
 N0 Reference Reference Reference Reference
 N1 3.60 (1.56–8.30) 0.003 0.36 (0.05–2.77) 0.324 3.93 (1.94–7.96) < 0.001 0.45 (0.06–3.46) 0.444
 N2 14.37 (6.11–33.82) < 0.001 1.03 (0.16–1.59) 0.854 12.25 (5.91–25.43) < 0.001 1.46 (0.20–2.30) 0.714
TNM stage: I-II/III-IV 6.43 (2.93–14.10) < 0.001 9.82 (3.15–83.55) 0.002 6.26 (3.22–12.18) < 0.001 9.67 (3.18–79.30) 0.012
Differentiation 0.61 (0.31–1.21) 0.157       
 Poor Reference    Reference Reference
 Median 0.63 (0.32–1.25) 0.189    0.80 (0.52–1.47) 0.286   
 High 0.72 (0.40–1.53) 0.279    0.75 (0.45–1.33) 0.248   
Perineural invasion 4.24 (2.21–8.14) < 0.001 1.57 (1.15–3.21) 0.041 2.12 (1.42–4.25) 0.002 2.09 (1.59–5.32) 0.020
Vascular invasion 2.72 (1.44–5.14) 0.002 1.23 (0.61–2.47) 0.075 1.78 (1.02–3.09) 0.041 1.63 (0.88–2.95) 0.133
Retrieved lymph node 0.85 (0.71–1.72) 0.533    0.79 (0.51–1.43) 0.273   
Postoperative complication 0.96 (0.84–1.98) 0.857    1.32 (0.70–2.41) 0.396   
  1. *lap laparoscopic