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Table 1 Comparison of parathyroid and concomitant thyroid disease in patients with PHPT vs. SHPT

From: Coexistent papillary thyroid carcinoma diagnosed in surgically treated patients for primary versus secondary hyperparathyroidism: same incidence, different characteristics

 

PHPT

SHPT

p-Value

No. cases

(%)

No. cases

(%)

General data

Number of patients

140

(64.5)

77

(35.5)

 

Mean age

54.6 ± 13

 

48.8 ± 12

 

0.001

Sex

< 0.001

 Male

15

39

 Female

125

38

 Female:male ratio

8:1

~ 1:1

 Preoperative PTH level [pg/ml]

357.51 ± 38.11

1020 ± 161.38

< 0.001

Parathyroid disease

Parathyroid surgery*

< 0.001

 Single gland parathyroidectomy

116

(82.8)

7

(9.1)

  Right superior gland

17

(14.7)

0

(0)

  Right inferior gland

11

(9.5)

1

(14.3)

  Left superior gland

47

(40.5)

1

(14.3)

  Left inferior gland

38

(32.8)

2

(28.6)

  Ectopic

3

(2.5)

0

(0)

  Unspecified

0

(0)

3

(42.8)

 Two glands parathyroidectomy

8

(5.7)

2

(2.6)

 Subtotal parathyroidectomy

10

(7.2)

66

(85.7)

 Multiple parathyroid surgeries

6

(4.3)

2

(2.6)

Parathyroid morphopatology results*

< 0.001

 Parathyroid carcinoma

1

(0.7)

 Parathyroid adenoma

92

(65.7)

3

(3.9)

 Adenomatous hyperplasia

47

(33.6)

74

(96.1)

  Nodular

27

(57.4)

59

(79.7)

  Diffuse

7

(14.9)

3

(4.1)

  Both nodular and diffuse

8

(17.1)

9

(12.1)

  Unspecified

5

(10.6)

3

(4.1)

Thyroid disease

Thyroid surgery

75

(53.6*)

31

(40.3*)

0.061

 Adenomectomy

4

(5.3**)

5

(16.1**)

 Lobectomy/Lobisthmectomy

21

(28**)

11

(35.5**)

  Right

7

(33.3**)

6

(63.6**)

  Left

14

(66.7**)

4

(36.4**)

 Subtotal thyroidectomy

1

(0.7**)

 Total thyroidectomy

48

(34.3**)

14

(45.6**)

 Multiple thyroid surgeries

1

(0.7**)

2

(2.6**)

Thyroid morphopathology result

Papillary thyroid carcinoma (PTC)

19

(13.6*)

(25.3**)

9

(11.7*)

(29**)

0.692

0.694

Benign lesions

 Thyroid adenoma

9

(12**)

 Adenomatous/colloid goiter

14

(18.7**)

14

(45.2**)

 Adenomatous/colloid goiter with adenomas

40

(53.3**)

10

(32.3**)

 Hashimoto thyroiditis with nodularization

12

(16**)

6

(19.4**)

 Graves Basedow disease

1

(3.2**)

  1. *percentage of PHPT or SHPT cases, respectively; **percentage of concomitant disease cases