Analysis of outcomes and predictors of long-term survival following resection for retroperitoneal sarcoma

BMC Surgery

Table 3 Univariate and multivariate analysis of clinicopathologic variables associated with disease-free survival in 61 patients who underwent resection for primary retroperitoneal sarcoma

Variable	N (%)	5-year Disease-free Survival (%)	Univariate Analysis P	Multivariate Analysis*
Variable	N (%)	5-year Disease-free Survival (%)	Univariate Analysis P	P	Hazard Ratio (95% CI)
Sex			.649
Male	29 (48)	38
Female	32 (52)	32
BMI (Body Mass Index)			.635
< 25	28 (46)	29
≥25	33 (54)	38
Patient age at resection			.006	NS
≥ 60 years	21 (35)	16
18–59 years	38 (62)	47
< 18 years	2 (3)	50
Tobacco use			.738
Yes	15 (25)	40
No	46 (75)	28
Tumour entity			.311
Leiomyosarcoma	19 (31)	31
Liposarcoma, dedifferentiated	14 (23)	22
Liposarcoma, well-differentiated	12 (20)	33
Undifferentiated sarcoma, NOS	8 (13)	25
Liposarcoma, pleomorphic	3 (5)	39
Malignant Peripheral Nerve Sheath Tumours	3 (5)	29
Other	3 (5)	66
Histologic grade, n (%)			.018	.013	2.07 (1.17–3.66)
Low grade (G1)	21 (34)	63
Intermediate grade (G2)	11 (18)	24
High grade (G3)	29 (48)	22
AJCC 8th Ed., n (%)			.004	NS
Stage IA	2 (3)	85
Stage IB	17 (28)	71
Stage II	4 (7)	50
Stage IIIA	8 (13)	36
Stage IIIB	25 (41)	28
Stage IV	5 (8)	0
Chemotherapy n (%)			.150
None	49 (80)	34
Neoadjuvant	2 (3)	50
Adjuvant	10 (16)	31
Radiotherapy			.330
None	44 (72)	33
Neoadjuvant	4 (7)	50
Adjuvant	13 (21)	66
Surgical resection margin			.047	.014	3.12 (1.26–7.72)
R0	33 (54)	53
R1	18 (30)	10
R2	2 (3)	0
RX / Not stated	8 (13)	44
Vascular involvement			.044	.001	5.04 (1.90–13.33)
Yes	17 (28)	33
No	44 (72)	39
ASA physical status			.659
I	12 (20)	48
II	32 (52)	36
III	14 (23)	23
IV	3 (5)	33
Need for intraoperative transfusions, %			.899
No RBCC	32 (52)	38
1–2 RBCC	13 (21)	41
≥ 3 RBCC	16 (26)	37

* Cox regression multivariate analysis included all variables with P < 0.05 in univariate analysis. CI Confidence interval, NS Not significant, BMI Body-mass-index, ASA American Society of Anesthesiologists, AJCC American Joint Committee on Cancer Staging Manual, NOS Not otherwise specified, RBCC Red blood cell concentrate
Entries with a p-value of < 0.05 in univariate or multivariate analysis are in boldface. A P value below 0.05 was considered significant.

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