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Table 1 Demographic and clinical data of reported cases of DSF after gastrectomy for malignant disease

From: Management of duodenal stump fistula after gastrectomy for malignant disease: a systematic review of the literature

Author/Year

Study period

Study type

Patients with DSF, n

Neoadjuvant chemotherapy, n

AJCC TNM stage

DSF diagnosis after operation, median days (range)

DSF output, median ml/day (range)

DSF-related complications

Garden et al./1988 [9]

1979–1985

RS

5

NA

NA

NA

1130 (120–2500)a

NA

Bloch et al./1989 [10]

1989

Case

1

0

I 1

NA

NA

NA

Kyzer et al./1997 [11]

1991–1994

RS

2

NA

NA

NA

NA

Sepsis (50%)

Wong et al./2000 [12]

1993–1997

RS

1

NA

NA

NA

210

Abdominal abscess

Oh et al./2009 [13]

1987–2004

RS

5

NA

NA

NA

NA

Sepsis (100%)

Lee et al./2009 [14]

2009

Case

1

0

I 1

7

NA

Abdominal abscess

Cozzaglio et al./2010 [5]

1991–2006

RS

68

2

NA

7 (0–22)

290 (40–2200)

Abdominal abscess (38%), Wound infection (28%), Sepsis (26%), Central line infection (15%), Pneumonia (13%), Acute renal failure (10%), Colonic fistula (7%), Pancreatic fistula (6%), Acute pancreatitis (6%), Intraabdominal bleeding (6%), Abdominal wall necrosis (4%), Pulmonary embolism (3%), Jejunal fistula (3%), Roux-en-Y syndrome (3%), Esophagojejunal fistula (3%), Heart failure (3%), Others (11%)

Hur et al./2010 [15]

2005–2007

RS

4

NA

NA

NA

NA

Abdominal abscess (100%)

Cozzaglio et al./2011 [16]

2005–2010

RS

6

NA

NA

6 (2–22)

500 (300–1000)

Sepsis (50%)

Curcio et al./2012 [17]

2012

Case

1

0

I 1

NA

NA

Abdominal abscess

Oh et al./2013 [18]

2005–2011

RS

10

NA

NA

10 (6–20)

NA

Abdominal fluids or abcess (100%)

Blouhos et al./2013 [19]

2013

Case

1

NA

IV 1

1

NA

Sepsis, Intra-abdominal bleeding

Vasiliadis et al./2014 [20]

2014

Case

1

NA

III 1

NA

NA

Dehydration and electrolyte disorders

Kim et al./2014 [21]

2002–2012

RS

13

NA

I 8, II 4, III 1

5 (1–12)

NA

NA

Orsenigo et al./2014 [3]

1987–2012

RS

32

0

I 7, II 9, III 9, IV 7

6.6 ± 4.7a

246 ± 266a

Sepsis (75%), Abdominal abscess (69%), Pneumonia (34%), Surgical site infection (28%), Intra-abdominal bleeding (22%), Acute renal failure (16%), Colonic fistula (12%), Gastro-jejunal anastomosis leakage (6%), Central line infection (6%), Pneumothorax (6%)

Cornejo et al./2016 [22]

1997–2014

RS

13

NA

I 4, II 5, III 2, IV 2

5 (3–7)a

NA

Sepsis (23%), Major Hematemesis (15%), Evisceration (8%), Abdominal abscess (8%)

Cozzaglio et al./2016 [4]

1990–2011

RS

75

3

NA

6 (2–11)

300 (100–750)

Abdominal abscess (70.7%); Sepsis (61.3%); Pneumonia (44%); Surgical site infection (38.7%); Digestive fistulas (29.3%); 2Acute renal failure (28%); Intra-abdominal bleeding (24%); Central line infection (17.3%); Acute pancreatitis (9.3%); Abdominal wall necrosis (8%); Others (21.3%)

Ali et al./2016 [7]

2010–2014

RS

24

NA

I 8, II 9, III 6, IV 1

8.5 (1–20)

NA

Pneumonia (20.8%), Sepsis (8.3%), Intra-abdominal bleeding (8.3%), Surgical site infection (8.3%), Deep vein thrombosis (8.3%)

Paik et al./2016 [6]

2008–2013

RS

16

NA

NA

6.5 (1–13)

NA

NA

Ramos et al./2018 [2]

2009–2017

RS

15

2

I/II 9, III/IV 6

9 (1–75)

NA

NA

  1. amean, NA not available